Evidence map›Paper›PMID 41963305›Full record

ReviewBlood cancer journal2026

Aberrant glycosylation in hematologic malignancies: mechanisms, immune evasion, and therapeutic targeting.

Xiao Lu, Zhouying Song, Chunhui Wang, Bing Pan, Ziqi Xu, Zilong Wang, Hequn Wang, Xiaobo Wang, Bo Tang

Abstract readReview
In one paragraph

Review in Blood cancer journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiao Lu *Department of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian, PR China.
Zhouying Song *Department of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian, PR China.
Chunhui WangDepartment of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian, PR China.
Bing PanDepartment of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian, PR China.
Ziqi XuDepartment of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian, PR China.
Zilong WangDepartment of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian, PR China.
Hequn WangDepartment of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian, PR China.
Xiaobo WangDepartment of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian, PR China. dlwangxiaobo@163.com.ORCID 0000-0001-5057-5919
Bo TangDepartment of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian, PR China. bo_tang@126.com.ORCID 0000-0002-0909-3034

Funding

Department of Education of Liaoning Province (Liaoning Provincial Education Department) No.LJ212410161037Natural Science Foundation of Liaoning Province (Liaoning Provincial Natural Science Foundation) 2024-MSLH-097
6 · The paper itself

Abstract

Hematologic malignancies are a group of malignant diseases originating from hematopoietic stem cells or the lymphatic system, mainly including leukemia, lymphoma, myeloma and so on. These diseases are characterized by their high heterogeneity, rapid disease progression and poor prognosis. Glycosylation is one of the most common post-translational modifications. In recent years, it has been found that abnormal glycosylation plays an important role in the genesis, development and treatment of hematologic malignancies. Aberrant glycosylation has been demonstrated to exert a significant influence on the progression of disease, impacting various biological processes including tumor cell signaling, the tumor microenvironment, cellular recognition, and immune evasion. This review synthesizes recent advances in how dysregulated glycosylation drives the biology of leukemia, lymphoma, myeloma, and other types of malignancies. Additionally, it discusses the potential value of glycosylation products that can be used as biomarkers for disease diagnosis and prognosis.

Indexed as

Hematologic NeoplasmsImmune EvasionAnimalsGlycosylationHumansMolecular Targeted TherapyProtein Processing, Post-TranslationalSignal TransductionTumor Microenvironment

Identifiers

PMID41963305
PMCPMC13180979

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.