Evidence map›Paper›PMID 41963321›Full record

ArticleNature communications2026

An immunobiliary single-cell atlas resolves crosstalk between type 2 conventional dendritic cells and γδ T cells in cholangitis.

Stefan Thomann, Helene Hemmer, Ankit Agrawal, Sukanya Basu, Judith Schaf, Nadine Vornberger, Tobias Krammer, Sagar, Fabian Imdahl, Tanja Poth and 8 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Stefan ThomannWürzburg Institute of Systems Immunology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.ORCID 0000-0002-3500-0014
Helene HemmerWürzburg Institute of Systems Immunology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.ORCID 0009-0001-9674-8907
Ankit AgrawalWürzburg Institute of Systems Immunology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.
Sukanya BasuWürzburg Institute of Systems Immunology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.ORCID 0009-0006-0410-8897
Judith SchafWürzburg Institute of Systems Immunology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.ORCID 0000-0002-8638-7490
Nadine VornbergerWürzburg Institute of Systems Immunology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.
Tobias KrammerHelmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Center for Infection Research (HZI), Würzburg, Germany.ORCID 0000-0002-7638-9476
SagarUniversity Hospital Freiburg, Department of Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, Freiburg, Germany.ORCID 0000-0002-8657-4704
Fabian ImdahlHelmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Center for Infection Research (HZI), Würzburg, Germany.
Tanja PothCenter for Model System and Comparative Pathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.ORCID 0009-0001-5612-4622
Marcell TóthUniversity Hospital Heidelberg, Institute of Pathology, Heidelberg, Germany.
Christina E ZielinskiLeibniz Institute for Natural Product Research and Infection Biology, Jena, Germany.
Tobias PochI. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Jenny KrauseI. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Andreas RosenwaldInstitute of Pathology, University of Würzburg, Würzburg, Germany.
Katja Breitkopf-HeinleinDepartment of Surgery, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID 0000-0002-1814-4796
Nuh RahbariDepartment of Surgery, University Hospital Ulm, Ulm, Germany.
Dominic GrünWürzburg Institute of Systems Immunology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany. dominic.gruen@uni-wuerzburg.de.ORCID 0000-0002-3364-5898

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The liver biliary niche serves as a reservoir of tissue-resident immune cells and supports tissue fibrosis upon damage, yet the role of peribiliary immune cells during cholangitis remains poorly understood. Here, we induce cholestatic liver injury mirroring human biliary diseases with bile acid retention in mice to establish a spatial and multimodal single-cell RNA-sequencing atlas of the liver and liver-draining lymph nodes (LN). We characterized a hepatic disease state trajectory from dendritic cell precursors (preDCs) to a mature subset of pro-inflammatory Mgl2

Indexed as

Dendritic CellsIntraepithelial LymphocytesReceptors, Antigen, T-Cell, gamma-deltaAnimalsCell CommunicationCholestasisDisease Models, AnimalHumansInterleukin-17LiverLymph NodesMaleMiceMice, Inbred C57BLSingle-Cell AnalysisInterleukin-17Receptors, Antigen, T-Cell, gamma-delta

Identifiers

PMID41963321
PMCPMC13076812

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.