Evidence mapPaperPMID 41963448Full record

ArticleScientific reports2026

Targeting CB1 and TRPM8 receptors to counteract CD8+ T cell exhaustion.

Adel Mohammadzadeh, Sahand Moazzendizzaji, Aliasghar Tabatabaei Mohammadi, Afsaneh Ahmadi, Rahim Mahmodlou, Ali Akbar Pourfathollah

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Adel MohammadzadehCellular and Molecular Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran. a.mohimm@gmail.com.
Sahand MoazzendizzajiDepartment of Immunology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Aliasghar Tabatabaei MohammadiSchool of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Afsaneh AhmadiDepartment of Infectious Diseases, Immigrant Health Clinic, Copenhagen University Hospital, Hvidovre, Denmark.
Rahim MahmodlouDepartment of General Surgery, Urmia University of Medical Sciences, Urmia, Iran.
Ali Akbar PourfathollahDepartment of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prolonged interaction between the immune system and tumor antigens can result in T cell exhaustion. Extensive research has been conducted on strategies to reactivate exhausted T cells within the tumor microenvironment. However the exact contribution of the endocannabinoid system (ECS) and nociceptors in regulating CD8+ T cells within the framework of cancer-related inflammation has not been thoroughly studied. This study investigated the use of a TRPM8 antagonist (RQ-00203078), a selective cannabinoid receptor 1 (CB1) antagonist (AM251), and alpelisib (BYL-719) to control CD8+ T cell exhaustion. Our findings showed that administration of the CB1 antagonist AM251, either alone or in combination with alpelisib, significantly reduced the expression of PD-1 and Lag-3 on CD8+ T cells. Interestingly, treatment with the TRPM8 antagonist led to a notable increase in PD-1 expression on CD8+ T cells. These findings suggest that the decreased expression of inhibitory receptors on CD8+ T cells after treatment with the CB1 antagonist whether alone or with alpelisib and TRPM8 highlights the potential of ECS as a promising therapeutic target in cancer treatment.

Indexed as

CD8-Positive T-LymphocytesReceptor, Cannabinoid, CB1T-Cell ExhaustionTRPM Cation ChannelsAnimalsAntigens, CDLymphocyte Activation Gene 3 ProteinMicePiperidinesProgrammed Cell Death 1 ReceptorPyrazolesAM 251Antigens, CDLymphocyte Activation Gene 3 ProteinPiperidinesProgrammed Cell Death 1 ReceptorPyrazolesReceptor, Cannabinoid, CB1TRPM Cation ChannelsAlpelisibCB1 and TRPM8 antagonistsCD8+ T cell exhaustionNeuro-immune interactionNociceptorsPD-1 and Lag-3

Identifiers

PMID41963448
PMCPMC13230856

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.