Evidence map›Paper›PMID 41963721›Full record

ReviewClinical reviews in allergy & immunology2026

Sexual Dimorphism in Allergic and Mast Cell-Associated Diseases.

Aditya Kotha, Tania D Maldonado, Hadi Hamze, Zakaria Y Hussain, Navya Gobinathan, An Z Yao, Mahamed Abudulkadir, John M Ching, John J Ryan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical reviews in allergy & immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aditya KothaSchool of Life Sciences and Sustainability, Virginia Commonwealth University, Richmond, VA, 23284, USA.
Tania D MaldonadoSchool of Life Sciences and Sustainability, Virginia Commonwealth University, Richmond, VA, 23284, USA.
Hadi HamzeSchool of Life Sciences and Sustainability, Virginia Commonwealth University, Richmond, VA, 23284, USA.
Zakaria Y HussainSchool of Life Sciences and Sustainability, Virginia Commonwealth University, Richmond, VA, 23284, USA.
Navya GobinathanSchool of Life Sciences and Sustainability, Virginia Commonwealth University, Richmond, VA, 23284, USA.
An Z YaoSchool of Life Sciences and Sustainability, Virginia Commonwealth University, Richmond, VA, 23284, USA.
Mahamed AbudulkadirSchool of Life Sciences and Sustainability, Virginia Commonwealth University, Richmond, VA, 23284, USA.
John M ChingSchool of Life Sciences and Sustainability, Virginia Commonwealth University, Richmond, VA, 23284, USA.
John J RyanSchool of Life Sciences and Sustainability, Virginia Commonwealth University, Richmond, VA, 23284, USA. jjryan@vcu.edu.

Funding

National Institute of Allergy and Infectious Diseases 1R01AI138495 and 1R03AI182614.
6 · The paper itself

Abstract

Allergic diseases are common, affecting more than one-third of the global population and varying widely in severity. A consistent theme in asthma, food allergy, atopic dermatitis, and chronic urticaria is a female-dominant prevalence in adulthood. Some of these begin with male predominance in childhood and shift with puberty. A smaller subset of allergic diseases, including eosinophilic esophagitis and vernal keratoconjunctivitis, has a clear male prevalence. In fact, nearly all allergic diseases exhibit sexual dimorphism in either prevalence or severity. These striking disparities are being unraveled to reveal mechanisms that might be clinically targeted. In this review, we discuss the current state of knowledge about sexual dimorphism for these important inflammatory disorders. These insights are foundational for optimizing personalized medicine.

Indexed as

HypersensitivityMast CellsSex CharacteristicsAnimalsFemaleHumansImmunoglobulin EMalePrevalenceImmunoglobulin EAllergic inflammationAllergyIgEInflammationSexual dimorphism

Identifiers

PMID41963721
PMCPMC13068717

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.