Evidence map›Paper›PMID 41963836›Full record

ArticleBMC nephrology2026

Multiparametric MRI as predictors for evaluating renal ischemia reperfusion injury and protective effect of Mito-TEMPO in rat model.

Jin-Lu Song, Zhen Xu, Yu-Hong Wang, Yu-Xin Qin, Wei Cui, Zhong-Yuan Cheng, You-Zhen Feng, Zi-Dong Xie, Xiang-Ran Cai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jin-Lu Song *Medical Imaging Center, The First Affiliated Hospital of Jinan University, No. 613 West Huangpu Avenue, Tianhe District, Guangzhou, Guangdong, 510630, China.
Zhen Xu *Medical Imaging Center, The First Affiliated Hospital of Jinan University, No. 613 West Huangpu Avenue, Tianhe District, Guangzhou, Guangdong, 510630, China.
Yu-Hong Wang *Institute of Gerontology, Guangzhou Geriatric Hospital, Guangzhou Medical University, No. 1288 Guangcong 10th Road, Zhongluotan Town, Baiyun District, Guangzhou, Guangdong, 510440, China.
Yu-Xin QinMedical Imaging Center, The First Affiliated Hospital of Jinan University, No. 613 West Huangpu Avenue, Tianhe District, Guangzhou, Guangdong, 510630, China.
Wei CuiMR Research, GE Healthcare, No. 2 Yongchang North Road, Economic and Technological Development Zone, Daxing District, Beijing, 100176, China.
Zhong-Yuan ChengMedical Imaging Center, The First Affiliated Hospital of Jinan University, No. 613 West Huangpu Avenue, Tianhe District, Guangzhou, Guangdong, 510630, China.
You-Zhen FengMedical Imaging Center, The First Affiliated Hospital of Jinan University, No. 613 West Huangpu Avenue, Tianhe District, Guangzhou, Guangdong, 510630, China. fengyouzhen@jnu.edu.cn.
Zi-Dong XieDepartment of Radiology, Wuzhou Red Cross Hospital, No. 3-1 Xinxing 1st Road, Wanshou District, Wuzhou, Guangxi, 543002, China. 57687219@qq.com.
Xiang-Ran CaiMedical Imaging Center, The First Affiliated Hospital of Jinan University, No. 613 West Huangpu Avenue, Tianhe District, Guangzhou, Guangdong, 510630, China. caixran@jnu.edu.cn.

Funding

Fundamental Research Funds for the Central Universities 21624219Medical Scientific Research Foundation of Guangdong Province A2024032National Natural Science Foundation of China 82202284National Natural Science Foundation of China 82372076Science and Technology Projects in Guangzhou 2024A04J4341Science and Technology Projects in Guangzhou 2025A03J3475
6 · The paper itself

Abstract

backgroundWe aimed to evaluate multiparametric magnetic resonance imaging (MRI), including blood oxygen level dependent (BOLD), arterial spin labeling (ASL), and intravoxel incoherent motion (IVIM) for noninvasively monitoring acute kidney injury (AKI) to acute kidney disease (AKD) progression following renal ischemia reperfusion injury (IRI) and the subsequent response to Mito-TEMPO (MT) therapy.

methodsPhase 1: 42 Sprague Dawley (SD) rats (36 IRI and 6 control). Phase 2: 144 SD rats (IRI/control + MT treatment/saline, 36 per group). IRI group: left renal ischemia reperfusion procedures, control group: sham abdominal surgery. Animals underwent MRI scanning to obtain effective transverse relaxation rate (R2*), renal blood flow (RBF), apparent diffusion coefficient (ADC), pure molecular diffusion (D), perfusion-related diffusion (D*), and perfusion fraction (f) values of kidney. After sacrifice, serological and histological analysis were performed.

resultsAll MRI parameters (R2*, RBF, ADC, D*, D, f) showed significant, time-dependent alterations following IRI compared to controls. These changes were effectively reversed by MT treatment, with most parameters recovering to near-baseline levels.

conclusionBOLD, ASL, and IVIM can be used as noninvasive radiologic markers for detecting the progression from renal IRI to AKI-AKD and recovery after MT treatment.

Indexed as

Acute Kidney InjuryCyclic N-OxidesKidneyMultiparametric Magnetic Resonance ImagingReperfusion InjuryAnimalsDisease Models, AnimalMalePerfusion Magnetic Resonance ImagingRatsRats, Sprague-DawleyRenal CirculationCyclic N-OxidesAcute kidney diseaseAcute kidney injuryIschemia reperfusion injuryMitochondria-targeted antioxidantMRI

Identifiers

PMID41963836
PMCPMC13191915

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.