ArticleBMC psychiatry2026
Frailty-related vulnerability and immune cell profiles in younger adults with schizophrenia: an exploratory study.
Article in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThis exploratory study aimed to compare frailty characteristics between patients with schizophrenia and healthy controls, and to investigate the association between frailty severity and immune-inflammatory markers in individuals with schizophrenia.
methodsWe recruited 27 community-dwelling patients with schizophrenia (mean age 39.9 ± 7.8 years) and 14 age-matched healthy controls (mean age 37.1 ± 8.4 years). Frailty was assessed using the Frailty Index-Laboratory (FI-Lab), the Edmonton Frail Scale (EFS), and the Clinical Frailty Scale (CFS). Immune-inflammatory markers were analyzed using flow cytometry. Statistical analyses examined group differences and associations with frailty severity.
resultsCompared to healthy controls, patients with schizophrenia showed significantly higher scores on FI-Lab, EFS, and CFS. Several immune cell subsets, including memory (CD45RO
conclusionsOur findings suggest that younger patients with schizophrenia may exhibit early signs of frailty and altered immune cell profiles. While limited by sample size and cross-sectional design, these findings highlight potential immune correlates of frailty-related vulnerability in this population. CLINICAL
trial registrationNot applicable.
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