Evidence map›Paper›PMID 41963884›Full record

SynthesisBMC surgery2026

Effect of negative pressure wound therapy on surgical wound outcomes in colorectal cancer surgery patients: a systematic review and meta-analysis.

Mohamed Sherif Ali Ahmed, Mostafa Ismail Mahmoud Hassan, Ahmed Ibrahim, Ahmed Lamey, Mahmoud M Elsayed, Ahmed Elshaboury, Mohamed Hamouda Elkasaby, Ahmed Abdelrafee

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohamed Sherif Ali AhmedMansoura University Hospital, Al Mansurah, Egypt. mohamedsherifaliahmed@gmail.com.
Mostafa Ismail Mahmoud HassanMansoura University Hospital, Al Mansurah, Egypt.
Ahmed IbrahimMansoura University Hospital, Al Mansurah, Egypt.
Ahmed LameyDepartment of General Surgery, Faculty of Medicine, Kafr Elsheikh University, Kafr el-Sheikh, Egypt.
Mahmoud M ElsayedNeurosurgery Department, Medical University of South Carolina, Charleston, USA.
Ahmed ElshabouryMansoura University Hospital, Al Mansurah, Egypt.
Mohamed Hamouda ElkasabyFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Ahmed AbdelrafeeGastrointestinal Surgery Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSurgical site infections (SSI) and wound complications are major concerns in colorectal cancer (CRC) surgery. Negative pressure wound therapy (NPWT) has been proposed to reduce these complications, but its efficacy specifically in CRC surgery remains uncertain. This meta-analysis evaluates the impact of NPWT on surgical wound outcomes compared to standard wound care in patients undergoing CRC surgery.

methodsA systematic search of PubMed, Scopus, Web of Science, and Cochrane Library was conducted up to February 10, 2025, for studies comparing NPWT with standard wound care in CRC surgery patients. The primary outcome was total wound complications. Risk ratios (RR) and mean differences (MD) were pooled using a random-effects model, with heterogeneity assessed using I² statistics.

resultsSix studies involving 343 patients (NPWT: 171, control: 172) were included. NPWT did not significantly reduce total wound complications (RR: 0.67, 95% CI: 0.35–1.26, P = 0.21, I² = 66%). Similarly, no significant differences were found for SSI (RR: 0.80, 95% CI: 0.45–1.43, P = 0.45), even after sensitivity analysis resolved heterogeneity (RR: 0.62, 95% CI: 0.33–1.17, P = 0.14, I² = 0%). NPWT also showed no significant benefit in preventing wound dehiscence (RR: 2.44, P = 0.35), seroma (RR: 0.87, P = 0.92), or reducing reintervention rates (RR: 0.69, P = 0.36). The length of hospital stay was comparable between groups (MD: -0.25 days, P = 0.80).

conclusionThis meta-analysis suggests that NPWT does not significantly reduce wound complications, SSI, or LOS in CRC surgery.

Indexed as

Colorectal NeoplasmsNegative-Pressure Wound TherapySurgical WoundSurgical Wound InfectionColorectal Surgical ProceduresHumansTreatment Outcomeand Wound ComplicationsColorectal Cancer SurgeryNegative Pressure Wound TherapyNPWTSurgical Site Infection

Identifiers

PMID41963884
PMCPMC13088833

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.