ReviewCell communication and signaling : CCS2026
From lipid modification to cell death: the diverse roles of S-palmitoylation in cell fate decisions.
Review in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Protein Palmitoylation as a Molecular Switch Linking Regulated Cell Death and Disease.Biomolecules · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
S-palmitoylation is a dynamic, reversible lipid modification that plays a crucial role in the regulation of various types of cell death. However, systematic insights into how S-palmitoylation modifications integrate and mediate crosstalk among diverse cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and cuproptosis, to ultimately determine cell fate remain elusive. We propose the concept of the “palmitoylation code,” which posits that S-palmitoylation affects substrate function and signaling pathways through site specificity, kinetic dynamics, and spatial distribution, ultimately regulating the cell’s decision between survival and death. This review describes the regulatory principles of this code in major cell death pathways and provides a comprehensive overview of palmitoylation-targeting strategies and pharmacological inhibitors through an examination of how targeting the “palmitoylation code” can modulate cell fate transitions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.