ArticleRadiation oncology (London, England)2026
Dosimetric advantages and clinical feasibility of a novel lateral decubitus position for left breast cancer patients undergoing PORT.
Article in Radiation oncology (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRadiation-induced cardiac toxicity remains a significant concern in breast cancer radiotherapy. Our institution developed a novel lateral decubitus position (nLDP) technique for patients unable to maintain deep inspiration breath-hold (DIBH) during postoperative radiotherapy (PORT). This study quantitatively evaluated the cardiac dosimetry benefits and setup errors of nLDP and compared its heart-sparing effects to DIBH within the low-risk patients (free breathing mean heart dose [FB–MHD] <4 Gy).
methodsPatients with left-sided breast cancer indicated for PORT were enrolled and stratified into three cohorts based on positioning and breathing techniques: Cohort 1 (nLDP in FB, nLDP-FB), Cohort 2 (supine position in FB, SP-FB), and Cohort 3 (SP in DIBH, SP-DIBH). The planning target volume (PTV) encompassed the whole breast/chest wall ± regional lymph nodes, and organs at risk (OARs) were delineated according to institutional protocols. While all patients were clinically treated without internal mammary node irradiation (IMNI), supplementary IMN-inclusive plans were generated specifically for Cohort 1 for dosimetric comparison. All plans utilized 6 MV photon intensity-modulated radiation therapy (IMRT). Dosimetric parameters, normal tissue complication probability (NTCP), anatomical heart-PTV distances, and setup errors were assessed. For the low-risk patients, cardiac dose reductions in nLDP were compared with DIBH.
resultsA total of 76 patients were analyzed: Cohort 1 (n = 28, median age 51.5 years, 75% underwent modified radical mastectomy [MRM]), Cohort 2 (n = 28, median age 50.5 years, 61% MRM), and Cohort 3 (n = 20, median age 45 years, 55% MRM). In Cohort 1, nLDP significantly reduced the mean doses and V5 Gy–V30 Gy to the whole heart and cardiac substructures compared to SP, regardless of IMNI inclusion, without compromising PTV coverage. Furthermore, nLDP significantly increased the heart–PTV distance and lowered the NTCP for cardiac mortality and contralateral breast secondary malignancy. The setup errors for nLDP remained below 0.5 cm, with no significant difference compared to SP. In patients with FB-MHD < 4 Gy, nLDP achieved heart dose reductions comparable to DIBH.
conclusionsThe nLDP offers an effective cardioprotective alternative to DIBH by significantly reducing cardiac doses without compromising PTV coverage and setup stability.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.