Evidence map›Paper›PMID 41964074›Full record

ArticleBiology of sex differences2026

Sex- and age-dependent mitochondrial dysfunction and cognitive impairment in a mouse model of familial hypercholesterolemia.

Nathasha Prado-Lopes, Daniel Fagundes, Letícia Tavares, Whitney Santos, Wellinghton Barros, Henrique Moschen, Márcia Mortari, Jair Goulart, Angélica Amato, Jade de Oliveira and 2 more

Abstract read
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In one paragraph

Article in Biology of sex differences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nathasha Prado-LopesLaboratory of Bioenergetics and Metabolism, Department of Genetics and Morphology, Institute of Biology, University of Brasília, Brasília, DF, Brazil.
Daniel FagundesLaboratory of Bioenergetics and Metabolism, Department of Genetics and Morphology, Institute of Biology, University of Brasília, Brasília, DF, Brazil.
Letícia TavaresLaboratory of Bioenergetics and Metabolism, Department of Genetics and Morphology, Institute of Biology, University of Brasília, Brasília, DF, Brazil.
Whitney SantosLaboratory of Bioenergetics and Metabolism, Department of Genetics and Morphology, Institute of Biology, University of Brasília, Brasília, DF, Brazil.
Wellinghton BarrosLaboratory of Bioenergetics and Metabolism, Department of Genetics and Morphology, Institute of Biology, University of Brasília, Brasília, DF, Brazil.
Henrique MoschenLaboratory of Bioenergetics and Metabolism, Department of Genetics and Morphology, Institute of Biology, University of Brasília, Brasília, DF, Brazil.
Márcia MortariLaboratory of Neuropharmacology, Department of Physiological Sciences, Biology Institute, University of Brasilia, Brasília, DF, Brazil.
Jair GoulartLaboratory of Bioenergetics and Metabolism, Department of Genetics and Morphology, Institute of Biology, University of Brasília, Brasília, DF, Brazil.
Angélica AmatoLaboratory of Bioenergetics and Metabolism, Department of Genetics and Morphology, Institute of Biology, University of Brasília, Brasília, DF, Brazil.
Jade de OliveiraDepartment of Biochemistry, Graduate Program in Biological Sciences: Biochemistry, Institute of Basic Health Sciences (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Paula BelloziLaboratory of Molecular Pharmacology, Department of Pharmacy, Faculty of Health Sciences, University of Brasília, Brasília, DF, Brazil.
Andreza Fabro de BemLaboratory of Bioenergetics and Metabolism, Department of Genetics and Morphology, Institute of Biology, University of Brasília, Brasília, DF, Brazil. debemandreza@gmail.com.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 404466/2023-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88881.465507/2019-01Fundação de Apoio à Pesquisa do Distrito Federal 00193-00002348/2022-07Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação 485489/2014-1
6 · The paper itself

Abstract

backgroundFamilial hypercholesterolemia (FH) is a genetic disorder of cholesterol metabolism caused by loss-of-function variants in the low-density lipoprotein receptor (LDLR), resulting in persistently elevated LDL-cholesterol levels in plasma. Although hypercholesterolemia, especially the high levels of LDL, has been linked to an increased risk of dementia, the underlying mechanisms remain unclear. Here, we investigated the effects of sexual dimorphism and aging on metabolic and cognitive functions in a murine model of FH.

methodsAdult and middle-aged, male and female, C57BL/6 and LDLr

resultsLDLr

conclusionsCollectively, these findings demonstrate that FH induces sex- and age-dependent alterations in behavior and mitochondrial metabolism, providing mechanistic insights into the link between FH and neurodegenerative disease risk.

Indexed as

AgingCognitive DysfunctionHyperlipoproteinemia Type IIMitochondriaSex CharacteristicsAnimalsDisease Models, AnimalFemaleHippocampusMaleMiceMice, Inbred C57BLMice, KnockoutReceptors, LDLSpatial MemoryReceptors, LDLAgingBehaviorHypercholesterolemiaMitochondriaSexual dimorphism

Identifiers

PMID41964074
PMCPMC13182057

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.