Evidence map›Paper›PMID 41964098›Full record

ArticleMicrobiome2026

Loss of salivary agglutinin induces changes in the salivary microbiome and accelerates development of oral cancer.

Marcell Costa de Medeiros, Simon Fontaine, Erika Danella, Ethan Hillman, Thomas M Schmidt, Allison Furgal, Deneen M Wellik, Naohiro Inohara, Gabriel Núñez, Gen Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiome, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marcell Costa de MedeirosPeriodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, USA.
Simon FontaineDepartment of Statistics, University of Michigan, 1011 North University Ave, Room G018, Ann Arbor, MI, 48109-1078, USA.
Erika DanellaPeriodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, USA.
Ethan HillmanDepartment of Bioinformatics, University of Michigan, Ann Arbor, USA.
Thomas M SchmidtDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, USA.
Allison FurgalDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, USA.
Deneen M WellikDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI, USA.
Naohiro InoharaDepartment of Pathology, University of Michigan, Ann Arbor, USA.
Gabriel NúñezDepartment of Pathology, University of Michigan, Ann Arbor, USA.
Gen LiDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, USA.
Grace Y ChenDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA.
Nisha J D'SilvaPeriodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, USA. njdsilva@umich.edu.

Funding

Exploring the Role of DMBT1 Suppression in Invasion of Oral CancerF30DE031940 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Erika Bunnine Danella · 2022 to 2026
$260k
NCI NIH HHS CA250214NIDCR NIH HHS F30 DE031940
6 · The paper itself

Abstract

backgroundSalivary agglutinin, also known as deleted in malignant brain tumors 1 (DMBT1), is an anti-microbial protein. DMBT1 is low in saliva from patients with oral squamous cell carcinoma (OSCC) and dramatically increases after treatment, with accompanying microbial changes. While this suggests an association between DMBT1 suppression and changes in the oral microbiota, causation has not been established. DMBT1 is also a tumor suppressor protein; its loss promotes OSCC progression, but its role in OSCC development is unknown. In this study, OSCC development was investigated in a murine carcinogen model that simulates human OSCC. Microbiota were standardized between Dmbt1 knockout (Dmbt1

resultsDespite microbiota standardization, Dmbt1

conclusionsThus, DMBT1 shapes salivary microbiota composition and protects against OSCC development. Dynamic, genotype-specific microbial shifts during carcinogenesis underscore the complex interplay between the oral microbiota and cancer progression. Video Abstract.

Indexed as

BacteriaCarcinoma, Squamous CellMicrobiotaMouth NeoplasmsReceptors, Cell SurfaceSalivaAnimalsCalcium-Binding ProteinsDisease Models, AnimalDNA-Binding ProteinsFemaleHumansMiceMice, KnockoutRNA, Ribosomal, 16STumor Suppressor ProteinsCalcium-Binding ProteinsDMBT1 protein, humanDNA-Binding ProteinsReceptors, Cell SurfaceRNA, Ribosomal, 16STumor Suppressor Proteins

Identifiers

PMID41964098
PMCPMC13188527

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.