Reconfiguration of Multiphase Coacervate Droplets Into Self-Regulated Nested Artificial Cells.

Zhuping Yin, Rui Sun, Jingxin Shao, Jan C M van Hest, Stephen Mann

Abstract read

In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhuping YinCentre for Protolife Research and Centre for Organized Matter Chemistry, School of Chemistry, University of Bristol, Bristol, UK.ORCID 0000-0002-8319-0553

Rui SunCentre for Protolife Research and Centre for Organized Matter Chemistry, School of Chemistry, University of Bristol, Bristol, UK.

Jingxin ShaoBio-Organic Chemistry, Departments of Biomedical Engineering and Chemical Engineering & Chemistry, Institute For Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands.

Jan C M van HestBio-Organic Chemistry, Departments of Biomedical Engineering and Chemical Engineering & Chemistry, Institute For Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands.ORCID 0000-0001-7973-2404

Stephen MannCentre for Protolife Research and Centre for Organized Matter Chemistry, School of Chemistry, University of Bristol, Bristol, UK.ORCID 0000-0003-3012-8964

Funding

China Scholarship CouncilERC Advanced Grant Scheme EC-2016-674 ADG 740235ERC Advanced Grant Scheme PRO-ARTIS 101141866Horizon Europe European Commission 101146274Horizon Europe European Commission MSCA-PFSwedish Research Council International Postdoc 2020-00747UKRI Horizon Europe Guarantee 101061428UKRI Horizon Europe Guarantee MSCA-PF

6 · The paper itself

Abstract

Dynamic sub-compartmentalization and internal organization are important assets of living cells to control functional complexity. Mimicking these features in artificial cells provides a platform to effectively respond to external cues by changing internal structure, thereby emulating life-like behavior. Here, we present a strategy to construct sub-compartmentalized artificial cells by converting multiphase coacervate droplets (MCDs) into nested coacervate vesicles (NCVs), in which the outer host domain is electrostatically reconfigured into a continuous semipermeable shell, while the internal guest droplets are preserved. The generated artificial cells exhibit spatial segregation of coacervate constituents and encapsulated fluorescent dyes, enzymes, and gold nanoparticles, and remain morphologically stable under different conditions. The membranized artificial cells display artificial metabolic features by means of poly(N-isopropylacrylamide) (PNIPAAm) synthesis and subsequent temperature-dependent aggregation, leading to emergent behavior including self-regulated photothermal transitions, feedback-mediated photocatalysis, and spatiotemporal organization of internal cargoes. Overall, our approach establishes a robust artificial cell platform that combines sub-compartmentalization with self-regulating properties, integrating functionality with structural complexity.

Indexed as

Acrylic ResinsArtificial CellsFluorescent DyesGoldMetal NanoparticlesTemperatureAcrylic ResinsFluorescent DyesGoldpoly-N-isopropylacrylamideartificial cellcoacervatenested coacervate vesicle

Identifiers

PMID41964199

DOI10.1002/anie.9334343

PMCPMC13182209

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.