Evidence map›Paper›PMID 41964606›Full record

ArticleJournal of medicinal chemistry2026

Ruthenium Complexes of Atovaquone Acting on Multiple Stages of the

Camila Fabbri, Pedro Henrique S Marcon, Aline de Sousa Santiago, Caroline Conceição Sousa, Helenita Costa Quadros, Larissa de Sena Lamar Nunes, Dione D Maciel de Menezes, Rosa Amélia Gonçalves Santana, Silvia Cássia B Justiniano, Sarah D'Alessandro and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Camila FabbriFundação de Medicina Tropical Dr. Heitor Vieira Dourado (FT-HVD), Unidade de Pesquisa Clínica Carlos Borborema, 69040-000 Manaus, AM, Brazil.
Pedro Henrique S MarconDepartamento de Química Fundamental. Instituto de Química, Universidade de São Paulo (USP). São Paulo, 05508-000 São Paulo, SP, Brazil.ORCID 0000-0001-9950-1128
Aline de Sousa SantiagoFundação de Medicina Tropical Dr. Heitor Vieira Dourado (FT-HVD), Unidade de Pesquisa Clínica Carlos Borborema, 69040-000 Manaus, AM, Brazil.
Caroline Conceição SousaInstituto Gonçalo Moniz. Fiocruz Bahia, 40296-710 Salvador, BA, Brazil.
Helenita Costa QuadrosInstituto Gonçalo Moniz. Fiocruz Bahia, 40296-710 Salvador, BA, Brazil.
Larissa de Sena Lamar NunesInstituto Leônidas e Maria Deane. Fiocruz Amazônia, 69057-070 Manaus, AM, Brazil.
Dione D Maciel de MenezesInstituto Leônidas e Maria Deane. Fiocruz Amazônia, 69057-070 Manaus, AM, Brazil.
Rosa Amélia Gonçalves SantanaFundação de Medicina Tropical Dr. Heitor Vieira Dourado (FT-HVD), Unidade de Pesquisa Clínica Carlos Borborema, 69040-000 Manaus, AM, Brazil.
Silvia Cássia B JustinianoFundação de Medicina Tropical Dr. Heitor Vieira Dourado (FT-HVD), Unidade de Pesquisa Clínica Carlos Borborema, 69040-000 Manaus, AM, Brazil.
Sarah D'AlessandroDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133 Milan, Italy.
Nicoletta BasilicoDipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Universitá degli Studi di Milano, 20133 Milan, Italy.
Diogo R M MoreiraInstituto Gonçalo Moniz. Fiocruz Bahia, 40296-710 Salvador, BA, Brazil.ORCID 0000-0003-3323-4404
João Honorato de Araujo-NetoDepartamento de Química Fundamental. Instituto de Química, Universidade de São Paulo (USP). São Paulo, 05508-000 São Paulo, SP, Brazil.ORCID 0000-0002-1127-6083
Stefanie Costa Pinto LopesFundação de Medicina Tropical Dr. Heitor Vieira Dourado (FT-HVD), Unidade de Pesquisa Clínica Carlos Borborema, 69040-000 Manaus, AM, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, we present the synthesis, characterization, and pharmacological evaluation of ruthenium complexes of broad-spectrum drug Atovaquone (ATV). Structure-activity relationships revealed key determinants for antiplasmodial activity, such as the importance of the oxidation state [Ru(III)

Indexed as

AntimalarialsAtovaquoneCoordination ComplexesLife Cycle StagesPlasmodiumPlasmodium falciparumRutheniumAnimalsHumansStructure-Activity RelationshipAntimalarialsAtovaquoneCoordination ComplexesRuthenium

Identifiers

PMID41964606
PMCPMC13181773

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.