Evidence map›Paper›PMID 41964798›Full record

ArticleDermatology and therapy2026

Genetic Markers of Tumor Multiplicity in Non-melanoma Skin Cancer: Associations of 19 SNPs in an Italian Cohort.

Irene Campana, Ylenia Aura Minafò, Giovanni Luca Scaglione, Giulia Giovanardi, Terenzio Cosio, Caterina Lanna, Fabio Artosi, Sara Lambiase, Carola Valente, Valeria Bartolocci and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dermatology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Skin Cancer Prevention and Antiaging: Role of Nicotinamide.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Irene CampanaMolecular and Cell Biology Laboratory, Istituto Dermopatico dell'Immacolata IDI-IRCCS, 00167, Rome, Italy.
Ylenia Aura MinafòMolecular and Cell Biology Laboratory, Istituto Dermopatico dell'Immacolata IDI-IRCCS, 00167, Rome, Italy.
Giovanni Luca ScaglioneBioinformatics Unit, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, 00167, Rome, Italy.
Giulia GiovanardiDepartment of Dermatology, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, 00167, Rome, Italy.
Terenzio CosioDermatology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133, Rome, Italy.
Caterina LannaDermatology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133, Rome, Italy.
Fabio ArtosiDermatology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133, Rome, Italy.
Sara LambiaseDermatology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133, Rome, Italy.
Carola ValenteMolecular and Cell Biology Laboratory, Istituto Dermopatico dell'Immacolata IDI-IRCCS, 00167, Rome, Italy.
Valeria BartolocciMolecular and Cell Biology Laboratory, Istituto Dermopatico dell'Immacolata IDI-IRCCS, 00167, Rome, Italy.
Martina MorelliExperimental Immunology Laboratory, Istituto Dermopatico dell'Immacolata IDI-IRCCS, 00167, Rome, Italy.
Cristina AlbanesiExperimental Immunology Laboratory, Istituto Dermopatico dell'Immacolata IDI-IRCCS, 00167, Rome, Italy.
Enzo PaleseDepartment of Dermatology, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, 00167, Rome, Italy.
Marilena MinieriDepartment of Experimental Medicine, University of Rome Tor Vergata, 00133, Rome, Italy.
Alfredo GiovannelliUnit of Laboratory Medicine, University Hospital Tor Vergata, 00133, Rome, Italy.
Daniele AvitabileIDI Farmaceutici S.r.l., 00071, Pomezia, Italy.
Nidia Margot SalcedoClinical Epidemiology Unit, Istituto Dermopatico dell'Immacolata IDI-IRCCS, 00167, Rome, Italy.
Simona MastroeniNational Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, 00161, Rome, Italy.
Cinzia MazzantiDepartment of Dermatology, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, 00167, Rome, Italy.
Damiano AbeniClinical Epidemiology Unit, Istituto Dermopatico dell'Immacolata IDI-IRCCS, 00167, Rome, Italy.
Elena CampioneDermatology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133, Rome, Italy.
Luca Fania *Department of Dermatology, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, 00167, Rome, Italy.
Elena Dellambra *Molecular and Cell Biology Laboratory, Istituto Dermopatico dell'Immacolata IDI-IRCCS, 00167, Rome, Italy. e.dellambra@idi.it.ORCID http://orcid.org/0000-0002-4329-3312

Funding

European Union Next Generation EU-PNRR M6C2-Investimento 2.1 Valorizzazione e potenziamento della ricerca biomedica del SSN PNRR-MCNT2-2023-12378474Ministero della Salute RF2016-02362541Ministero della Salute Ricerca Corrente RC2020-23
6 · The paper itself

Abstract

introductionUltraviolet exposure is the main environmental risk factor for non-melanoma skin cancers (NMSCs), but genetic susceptibility also contributes to variability in disease burden among individuals.

methodsThis study analyzed selected single-nucleotide polymorphisms (SNPs) in genes related to vitamin D and nicotinamide adenine dinucleotide metabolism, DNA repair, inflammation, and pigmentation as potential biomarkers for NMSC risk in an Italian cohort. Participants were stratified into low- and high-risk groups on the basis of tumor burden.

resultsNo significant differences were observed in demographic or phenotypic factors between the groups; however, chronic sun exposure was associated with an increased risk. A total of 19 SNPs showed significant associations with NMSC multiplicity. Most of these SNPs were noncoding variants that likely influence gene expression or transcript stability. Specific variants in the NNMT, NFKBIA, ERCC6, XPA, LIG1, LIG3, and ZNF365 genes were more prevalent in individuals at high risk. Literature-based functional data indicate that the identified NFKBIA and ERCC6 SNPs are particularly relevant to NMSC risk, as NFKBIA variants may promote inflammation, and the ERCC6 variant can impair DNA repair.

conclusionsThese results underscore the significance of regulatory genetic variation in NMSC susceptibility. The identified SNPs could represent useful biomarkers for genetic risk stratification and support the development of personalized prevention strategies based on genetic profiles.

trial registrationProtocol no.: 518-2/19-12-2019.

Indexed as

DNA repairGenetic riskInflammationNon-melanoma skin cancerPrecision preventionSingle-nucleotide polymorphisms

Identifiers

PMID41964798
PMCPMC13237332

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.