Evidence map›Paper›PMID 41964950›Full record

ArticleCell reports2026

A Rasa3-Gαi signaling axis orchestrates B lymphocyte trafficking into and through lymphoid organs.

Chung Park, Il-Young Hwang, Kathleen Harrison, Ning-Na Huang, Margery Smelkinson, Sundar Ganesan, Han G Kim, Pamela L Schwartzberg, John H Kehrl

Abstract read
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In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chung ParkB Cell Molecular Immunology Section, National Institutes of Health, Bethesda, MD 20892, USA.
Il-Young HwangB Cell Molecular Immunology Section, National Institutes of Health, Bethesda, MD 20892, USA.
Kathleen HarrisonB Cell Molecular Immunology Section, National Institutes of Health, Bethesda, MD 20892, USA.
Ning-Na HuangB Cell Molecular Immunology Section, National Institutes of Health, Bethesda, MD 20892, USA.
Margery SmelkinsonBiological Imaging Section, Research Technologies Branch, National Institutes of Health, Bethesda, MD 20892, USA.
Sundar GanesanBiological Imaging Section, Research Technologies Branch, National Institutes of Health, Bethesda, MD 20892, USA.
Han G KimB Cell Molecular Immunology Section, National Institutes of Health, Bethesda, MD 20892, USA.
Pamela L SchwartzbergCell Signaling and Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
John H KehrlB Cell Molecular Immunology Section, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: jkehrl@niaid.nih.gov.

Funding

SIGNAL TRANSDUCTION IN B LYMPHOCYTES: INDENTIFICATION OF KEY SIGNALING MOLECULEZ01AI000739 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI KEHRL, JOHN H · 1996 to 2008
$1.5M
Intramural NIH HHS Z01 AI000739
6 · The paper itself

Abstract

By modulating integrin affinity, the GTP/GDP status of Rap1 affects the arrest, transendothelial migration, and the trafficking of lymphocytes, yet how chemoattractant receptors control Rap1 remains incompletely resolved. Rasa3, a Rap1 GTPase-activating protein, limits the duration that Rap1 remains GTP bound. Here, we investigated how Rasa3 deficiency impacted chemoattractant receptor signaling and B lymphocyte trafficking in mice. The loss of Rasa3 disrupted the usual dynamic regulation of the GDP/GTP status of Rap1 causing a striking phenotype characterized by a severe maldistribution of B cells within lymphoid organs and major reductions in mucosal and blood B cells. Rasa3 loss raised basal Rap1-GTP levels, disrupted integrin binding, and unexpectedly caused defects in chemoattractant receptor signaling. At the plasma membrane GTP-bound but not GDP-bound Gαi resided within 10 angstroms of Rasa3. Thus, Rasa3 couples Gαi signaling to Rap1-GTP levels tuning chemokine signaling and integrin affinity to promote B lymphocyte trafficking and function.

Indexed as

B lymphocytesCP: Immunologyheterotrimeric G proteinintravital imaginglymphocytes migrationmucosal immunityPeyer’s patchesRap1Rasa3

Identifiers

PMID41964950
PMCPMC13248921

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.