ArticleJACC. Advances2026
Arterial Stiffness Mechanisms and Orthostatic Hypotension in SPRINT: A Randomized Controlled Trial.
Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01206062 (Systolic Blood Pressure Intervention Trial), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Systolic Blood Pressure Intervention Trial
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7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertension is a leading cardiovascular disease risk factor. Intensive blood pressure (BP) control reduces cardiovascular disease events but may be limited by treatment-related serious adverse events (SAEs).
objectivesThe purpose of this study was to determine if baseline carotid to femoral pulse wave velocity (PWV)-including the component of structural stiffening, due to remodeling of the vessel wall, and load-dependent stiffening, due to the BP load on the arterial wall-is independently associated with orthostatic hypotension (OH) and SAEs in the SPRINT (Systolic Blood Pressure Intervention Trial).
methodsSPRINT compared intensive (<120 mm Hg) vs standard (<140 mm Hg) systolic BP goals. Carotid-femoral PWV was measured in 642 participants at baseline. Structural stiffening and load-dependent stiffening were calculated by adjusting PWV to a 120/80 mm Hg reference BP with participant-specific models. The association of PWV with OH and with other SAEs was assessed using negative binomial regression.
resultsOver a 3.0-year median follow-up, the cumulative SAE incidence was 38.7% in the intensive group and 35.1% in the standard group. OH was the most frequent event (27.0% standard; 24.4% intensive). Higher load-dependent PWV was associated with greater numbers of OH events (P = 0.005) regardless of treatment group. Higher total PWV was associated with greater rates of SAEs (P = 0.001) and this was largely driven by the association with load-dependent PWV (P < 0.001).
conclusionsLoad-dependent stiffness is associated with SAEs, including OH, regardless of BP treatment intensity. Load-dependent PWV may serve as a valuable clinical tool to identify patients who require enhanced surveillance before initiating intensive BP treatment. (Systolic Blood Pressure Intervention Trial SPRINT]; NCT01206062).
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