Evidence mapPaperPMID 41965323Full record

ArticleExperimental physiology2026

Metabolomic responses are more sensitive in muscle than serum following 28 days of arduous exercise with erythropoietin administration.

Devin J Drummer, Emily E Howard, Julie L McNiff, Marques A Wilson, Christopher T Carrigan, Nancy E Murphy, Jess A Gwin, David E Barney, Benjamin J Ryan, James P McClung and 2 more

Abstract read
In one paragraph

Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Devin J DrummerMilitary Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.ORCID https://orcid.org/0000-0002-8003-562X
Emily E HowardMilitary Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.
Julie L McNiffMilitary Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.
Marques A WilsonMilitary Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.
Christopher T CarriganMilitary Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.
Nancy E MurphyMilitary Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.
Jess A GwinMilitary Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.
David E BarneyMilitary Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.
Benjamin J RyanThermal and Mountain Medicine Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.
James P McClungMilitary Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.
Stefan M PasiakosMilitary Performance Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.
Lee M MargolisMilitary Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.ORCID https://orcid.org/0000-0002-0652-1304

Funding

Military Operational Medicine Research ProgramOak Ridge Institute for Science and Education
6 · The paper itself

Abstract

Erythropoietin (EPO) administration stimulates haematological and non-haematological adaptations that alter substrate oxidation and enhance aerobic performance. The effects of strenuous exercise and EPO on metabolites, and whether any effect is associated with haematological and non-haematological adaptations, has not been assessed. The objective of this study was to examine changes in serum and skeletal muscle metabolomes and explore whether changes were associated with haematological and non-haematological adaptations to strenuous exercise and EPO. Eight males (20 ± 3 years, 25 ± 3 kg/m

Indexed as

ErythropoietinExerciseMetabolomeMuscle, SkeletalAdaptation, PhysiologicalAdultEnergy MetabolismHumansIronLongitudinal StudiesMaleMetabolomicsOxygen ConsumptionYoung AdultErythropoietinIronaerobic exercisenetwork biologysubstrate utilization

Identifiers

PMID41965323
PMCPMC13131109

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.