ArticleScientific reports2026
Central and peripheral analgesia in irradiated rats: reserpine-induced pain model.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Over one-third of the world's population suffers from persistent or recurrent pain. Thus, this study was designed to investigate the possible analgesic effect offered by a low gamma-irradiation dose, as well as to elucidate its mechanisms of action; either through central, peripheral or indirect analgesia via the attenuation of oxidative stress and/or inflammation that are the proposed components of pain induction in the reserpine-induced model. Thirty male rats were divided into: group I (Normal), group II (Reserpine), group III (Reserpine + Radiation), groups IV (Reserpine + Naloxone + Radiation), and group V (Reserpine + Diclofenac). Pain assessment by tail-flick test and Haffner's tail clip method were performed, in addition to estimation of serum substance-P (SP) and tumor necrosis factor-α (TNF-α) levels, and brain contents of nitric oxide (NO), malondialdehyde (MDA) and dopamine (DA). Results displayed that administration of reserpine induced a significant reduction in both peripheral and central pain thresholds. However, low dose radiation induced a significant delay in pain latency in both tail-flick and Haffner's tail clip tests, as compared to reserpine untreated group. Low dose radiation peripheral analgesic effect was similar to the analgesia offered by diclofenac. Low dose irradiation-induced analgesia revealed in Haffner's clip test was significantly blocked upon the administration of naloxone prior to irradiation as compared to the reserpine + radiation group. Also, this study showed that the reserpine intoxication induced an elevation in rat brain MDA and NO, and serum TNF-α and SP levels, as well as a significant reduction in brain DA content as compared to the normal group. On the other hand, irradiation of reserpinized rats resulted in a restoration of all these parameters. Finally, it could be concluded that low radiation dose exerts analgesic effects through functional modulation of nociceptive pathways, potentially involving opioid-related mechanisms, as well as antioxidant and/or anti-inflammatory effects.
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