ArticleThe Plant cell2026
A simple cell-cycle control system in Marchantia polymorpha provides a framework for understanding plant cell proliferation.
Article in The Plant cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Engineering Auronidin Production in Marchantia polymorpha Enables a New Class of Plant-Derived Textile Pigments.ACS synthetic biology · 2026Article
- The hidden life of unicellular red algae: discovery of a common sexual cycle unlocks a model lineage for eukaryotic evolution.The Plant cell · 2026Article
- Setting the stage: the sleek cell-cycle machinery of the liverwort Marchantia polymorpha.The Plant cell · 2026Article
- Initiation of asexual reproduction by the AP2/ERF gene GEMMIFER in Marchantia polymorpha.Current biology : CB · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Eukaryotic cell division is controlled by cyclins and cyclin-dependent kinases (CDKs). The high number of cyclin-CDK pairs in flowering plants hinders functional analysis due to redundancy, and how this system might have worked in early land plant ancestors remains unresolved. Our phylogenetic analysis showed that non-seed plants have a simple system of cell cycle genes, suggesting that the complexity in seed plants is a derived feature. To explore simpler systems, we studied the liverwort Marchantia polymorpha, which possesses a reduced, nonredundant set of core cell cycle genes. Single-cell RNA-seq and live imaging of fluorescent reporters revealed phase-specific expression of cell cycle genes during cell division, characterized by 1 predominant cyclin per phase in the vegetative gametophyte, with limited overlap at transitions. Live imaging of tagged cyclins indicated that protein turnover and localization contribute to phase specificity. Functional studies revealed that MpCYCD;1 is sufficient to promote cell cycle re-entry, while overexpression of MpCYCA and MpCYCB;1 causes growth arrest, consistent with their roles in the G1, S, and G2/M transitions. Our findings reveal conserved features of cell cycle control across eukaryotes and the ancestral state of land plants. Marchantia thus provides a powerful framework for understanding multicellular proliferation and its evolution, with the potential for engineering plant growth and development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.