Evidence map›Paper›PMID 41967926›Full record

ArticleRenal failure2026

Bergamottin pretreatment attenuates cisplatin-induced acute kidney injury in mice by inhibiting BACE-1-mediated ferroptosis.

Xue-Ping Yang, Ya-Jie Wang, You-Song Xu, Song Peng, Hui-Feng Yuan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xue-Ping YangDepartment of Intensive Care Unit, The Third Affiliated Hospital of Anhui Medical University (the First People's Hospital of Hefei), Hefei, Anhui, China.
Ya-Jie WangDepartment of Intensive Care Unit, The Third Affiliated Hospital of Anhui Medical University (the First People's Hospital of Hefei), Hefei, Anhui, China.
You-Song XuDepartment of Intensive Care Unit, The Third Affiliated Hospital of Anhui Medical University (the First People's Hospital of Hefei), Hefei, Anhui, China.
Song PengDepartment of Critical Care Medicine, The Third Affiliated Hospital of Anhui Medical University (South District of Hefei First People's Hospital), Hefei, Anhui, China.
Hui-Feng YuanDepartment of Intensive Care Unit, The Third Affiliated Hospital of Anhui Medical University (the First People's Hospital of Hefei), Hefei, Anhui, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bergamottin is a natural furanocoumarin compound that possesses antioxidative and anticancer properties. However, the effect of bergamottin (BGM) on acute kidney injury (AKI) is unknown. Human renal tubular HK-2 cells and mice that received cisplatin were pretreated with BGM, after which their cytotoxicity and renal function were evaluated. BGM pretreatment alleviated cisplatin-induced cytotoxicity

Indexed as

Acute Kidney InjuryAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesCisplatinFerroptosisFurocoumarinsAnimalsApoptosisCell LineDisease Models, AnimalHumansMaleMiceMice, Inbred C57BLMolecular Docking SimulationAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesbergamottinCisplatinFurocoumarinsacute kidney injuryBACE-1BergamottinferroptosisGPX4

Identifiers

PMID41967926
PMCPMC13072673

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.