Circadian disruption of brain temperature and heart rate in two periods after intracerebral hemorrhage surgery: a retrospective study.

Lu-Ting Kuo, Ue-Cheung Ho, Hsueh-Yi Lu

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 authors.

Lu-Ting KuoDivision of Neurosurgery, Department of Surgery, National Taiwan University Hospital, Yunlin Branch, No. 579, Sec. 2, Yunlin Rd., Douliu, 640, Yunlin County, Taiwan. kuoluting@gmail.com.ORCID http://orcid.org/0000-0002-1405-8700

Ue-Cheung HoDivision of Neurosurgery, Department of Surgery, National Taiwan University Hospital, No. 7, Chung Shan South Road, Taipei, 100, Taiwan.

Hsueh-Yi LuDepartment of Industrial Engineering and Management, National Yunlin University of Science and Technology, 123 University Rd., Section 3, Douliou, 640, Yunlin County, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracerebral hemorrhage (ICH) remains a severe subtype of stroke with limited tools to predict postoperative outcomes. This retrospective study investigated postoperative brain temperature (BrT) and heart rate (HR) rhythms in 74 surgically treated ICH patients and evaluated their associations with 1-year outcomes. BrT and HR data from two postoperative periods (1-60 h [A] and 61-120 h [B]) were analyzed using the Cosinor method to determine circadian rhythmicity. BrT and HR rhythms were observed in 60.8% and 36.4% of patients, respectively, and rhythm transitions occurred in 35.1% and 43.2%. Multivariable analysis identified age, initial Glasgow Coma Scale (GCS) score, BrT rhythm in period B, and HR mesor in period A as independent predictors of 1-year functional outcome, whereas only initial GCS predicted mortality. Postoperative analysis of BrT and HR rhythms reveals dynamic alterations in physiological cycles after ICH and offers additional prognostic information beyond conventional clinical parameters.

Indexed as

Body TemperatureBrainCerebral HemorrhageCircadian RhythmHeart RateAgedFemaleGlasgow Coma ScaleHumansMaleMiddle AgedPostoperative PeriodPrognosisRetrospective StudiesBrain temperatureCircadian rhythmHeart rateIntracerebral hemorrhagePrognosisSurgery

Identifiers

PMID41968127

DOI10.1038/s41598-026-47437-2

PMCPMC13230590

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LicenceCC BY-NC-ND

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