Evidence map›Paper›PMID 41968288›Full record

ArticleJournal of neuroendocrinology2026

Arcuate nucleus-specific progesterone receptor knockdown in female mice is sufficient to induce PCOS-like hyperactivity in the reproductive axis.

Kelly A Glendining, Melanie Prescott, Kyoko Potapov, Elodie Kip, Rebecca E Campbell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroendocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kelly A GlendiningCentre for Neuroendocrinology and Department of Physiology, Faculty of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Melanie PrescottCentre for Neuroendocrinology and Department of Physiology, Faculty of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Kyoko PotapovCentre for Neuroendocrinology and Department of Physiology, Faculty of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Elodie KipCentre for Neuroendocrinology and Department of Physiology, Faculty of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Rebecca E CampbellCentre for Neuroendocrinology and Department of Physiology, Faculty of Biomedical Sciences, University of Otago, Dunedin, New Zealand.ORCID https://orcid.org/0000-0002-0309-532X

Funding

Health Research Council of New Zealand 23-332Marsden Fund 23-123
6 · The paper itself

Abstract

Mammalian reproductive function is dependent upon gonadal steroid hormone feedback within the hypothalamic-pituitary-gonadal (HPG) axis. In polycystic ovary syndrome (PCOS), impaired progesterone (P4) negative feedback leads to hyperactive pulsatile secretion of luteinising hormone (LH) and impaired reproductive function. Although the precise upstream neuronal network modulating P4 negative feedback remains undefined, gamma-aminobutyric acid (GABA)ergic neurons in the arcuate nucleus (ARC) have been implicated. To identify the critical location of P4 negative feedback, we knocked out progesterone receptors (PR) specifically from GABA neurons by genetic cross (VGAT-Cre; PR

Indexed as

Arcuate Nucleus of HypothalamusPolycystic Ovary SyndromeReceptors, ProgesteroneAnimalsEstrous CycleFeedback, PhysiologicalFemaleGABAergic NeuronsGene Knockdown TechniquesHypothalamic-Pituitary-Gonadal AxisLuteinizing HormoneMiceMice, KnockoutProgesteroneLuteinizing HormoneProgesteroneReceptors, ProgesteronefertilityGnRHPCOSprogesterone

Identifiers

PMID41968288
PMCPMC13071148

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.