Evidence map›Paper›PMID 41968361›Full record

ArticleImplementation science communications2026

Adapting the HealthMpowerment (HMP) mobile application for youth living with or at risk of HIV in Africa using the ADAPT-ITT model.

Julia Brasileiro, Kathryn E Muessig, Taylor Lascko, Nadia A Sam-Agudu, Aimee Rochelle, Megan E Mansfield, Akipu Ehoche, Sylvia Adebajo, Lisa B Hightow-Weidman, Manhattan E Charurat and 10 more

Registry-linked trialAbstract read
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In one paragraph

Article in Implementation science communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06350682 (Resilient HIV Implementation Science With SGM Youths Using Evidence), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06350682 naenrolling by invitationnot on this map

Resilient HIV Implementation Science With SGM Youths Using Evidence

TypeinterventionalSponsorUniversity of Maryland, BaltimoreRan2026 to 2029Enrolled1,500ConditionsHivArmsHealthMPowerment (HMP)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Julia BrasileiroInstitute on Digital Health and Innovation, College of Nursing, Florida State University, Tallahassee, FL, USA.
Kathryn E MuessigInstitute on Digital Health and Innovation, College of Nursing, Florida State University, Tallahassee, FL, USA.
Taylor LasckoCenter for International Health, Education, and Biosecurity, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
Nadia A Sam-AguduGlobal Pediatrics Program and Division of Infectious Diseases, University of Minnesota Medical School, Minneapolis, MN, USA.
Aimee RochelleInstitute on Digital Health and Innovation, College of Nursing, Florida State University, Tallahassee, FL, USA.
Megan E MansfieldCenter for International Health, Education, and Biosecurity, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
Akipu EhocheCenter for International Health, Education, and Biosecurity, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
Sylvia AdebajoCenter for International Health, Education, and Biosecurity, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
Lisa B Hightow-WeidmanInstitute on Digital Health and Innovation, College of Nursing, Florida State University, Tallahassee, FL, USA.
Manhattan E CharuratCenter for International Health, Education, and Biosecurity, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
Elizabeth ShoyemiCentre for Population Health Initiatives, Lagos, Nigeria.
Cassidy W ClaassenCenter for International Health, Education, and Biosecurity, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
Gift TrapenceCentre for the Development of People, Lilongwe, Malawi.
Joshua KimaniPartners for Health and Development in Africa, Nairobi, Kenya.
Ojore Godday AghedoCentre for Population Health Initiatives, Lagos, Nigeria.
Olawole AyorindeInternational Research Center of Excellence, Institute of Human Virology, Nigeria, Abuja, Nigeria.
Kennedy SambambiCiheb-Zambia, Lusaka, Zambia.
Gift NdalumbiraCentre for the Development of People, Lilongwe, Malawi.
Richard GichukiPartners for Health and Development in Africa, Nairobi, Kenya.
Marie-Claude C LavoieCenter for International Health, Education, and Biosecurity, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA. mlavoie@ihv.umaryland.edu.ORCID http://orcid.org/0000-0003-3315-6207

Funding

Resilient HIV Implementation Science with Sexual and Gender Minority Youths using Evidence (RISE) Clinical Research CenterUG1HD113162 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI Sylvia Adebajo, Manhattan E Charurat · 2023 to 2026
$4.9M
NICHD NIH HHS UG1 HD113162NIH HHS UG1HD113162
6 · The paper itself

Abstract

backgroundAdaptation plays a critical role in implementation science (IS) by optimizing the fit of evidence-based interventions (EBIs) to local contexts and populations. Adaptation is especially relevant in digital health, where technologies, user preferences, and needs evolve rapidly. Yet, methodological approaches to guide and document adaptation processes are seldom included. Grounded in an IS framework, we describe a multi-phase process and results for the adaptation of a digital health intervention (DHI) for HIV prevention and treatment for sexual and gender minority (SGM) youth in Malawi, Kenya, Nigeria, and Zambia.

methodsGuided by the Assessment, Decision, Administration, Production, Topical Experts, Integration, Training, and Testing (ADAPT-ITT) model, we adapted the EBI HealthMpowerment (HMP) DHI for SGM youth. We conducted eight focus group discussions with SGM youth (N = 80) living with or at risk for HIV and four with other key experts (N = 29) to inform app adaptations. Rapid qualitative analyses were conducted, and the findings were summarized using the Mobile App Rating Scale. Subsequently, we conducted beta testing with 40 SGM youth to assess the app's usability with the validated System Usability Scale. The data were collected from June 2024 to April 2025.

resultsMost HMP adaptations were within two domains of the Mobile App Rating Scale: Engagement and Information Quality. Engagement adaptations focused on increasing support and reducing provider response times through the app, along with added gamification. Information Quality adaptations focused on expanding resources (e.g., mental health, economic strengthening) and ensuring that healthcare referrals made via the app were to SGM-competent providers. Functionality enhancements included adding content in local languages and integrating WhatsApp. Data safety was prioritized and addressed by creating an emergency lockout code. For Subjective Quality, participants perceived the app favorably for its support for medication adherence. Results from the beta testing indicated a score of 70.0, indicating above-average usability. Modifications were made to the ADAPT-ITT model to embed consultations with key experts throughout the different phases.

conclusionsThe HMP app was collaboratively and iteratively adapted with SGM youth and key partners. This methodological approach enhances HMP's functionality, quality, and safety, increasing the likelihood of success in future trials and scale-up.

trial registrationNCT06350682. Registered on February 20, 2024. https://reporter.nih.gov/project-details/11373152.

Indexed as

AdaptationAfricaDigital health interventionsHIVPre-exposure prophylaxisRandomized controlled trialsYouth

Identifiers

PMID41968361
PMCPMC13244836

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.