Evidence map›Paper›PMID 41968401›Full record

ArticleNeurogastroenterology and motility2026

Brain Changes Underlying Irritable Bowel Syndrome Symptom Improvement in Response to Mindfulness-Based Stress Reduction.

Jennifer S Labus, Guistinna Tun, Paul W Savoca, Desiree R Delgadillo, Kevin Antony, Cathy Liu, Suzanne R Smith, J Greg Serpa, Jean Stains, Bruce Naliboff and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jennifer S LabusOppenheimer Center for Neurobiology of Stress and Resilience, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Guistinna TunOppenheimer Center for Neurobiology of Stress and Resilience, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Paul W SavocaOppenheimer Center for Neurobiology of Stress and Resilience, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Desiree R DelgadilloOppenheimer Center for Neurobiology of Stress and Resilience, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Kevin AntonyOppenheimer Center for Neurobiology of Stress and Resilience, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Cathy LiuOppenheimer Center for Neurobiology of Stress and Resilience, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Suzanne R SmithOppenheimer Center for Neurobiology of Stress and Resilience, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
J Greg SerpaVeterans Health Administration Office of Patient Centered Care and Cultural Transformation, Washington, DC, USA.
Jean StainsOppenheimer Center for Neurobiology of Stress and Resilience, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Bruce NaliboffOppenheimer Center for Neurobiology of Stress and Resilience, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Kirsten TillischOppenheimer Center for Neurobiology of Stress and Resilience, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

Funding

NCCIH NIH HHS AT007137
6 · The paper itself

Abstract

backgroundAlthough the efficacy of mindfulness-based interventions for improvements in IBS symptoms has been demonstrated, the specific neural mechanisms contributing to these changes remain unclear.

methodsA single arm interventional design was employed to explore functional brain network changes underpinning IBS symptom improvement in response to an 8-week mindfulness-based stress reduction (MBSR) intervention. Differences in brain resting state functional connectivity (RSFC) changes between 32 MBSR Responders and 16 Nonresponders with IBS after MBSR were computed using general linear models. An elastic-net regression model determined which RSFC changes were most impactful in determining MBSR responder status. Integrative association analyses elucidated the relationships between RSFC and symptom changes post MBSR. KEY

resultsFollowing MBSR, Responders compared to Nonresponders showed large effect size decreases in IBS symptom severity and increased mindfulness. Responder status was associated with widespread changes in RSFC. In particular, decreases in the intrinsic connectivity of the default mode network along with decreased cognitive control-somatomotor network connectivity after MBSR contributed 56% variance explained in IBS symptom severity improvement. Decreases in these two connections were associated with extensive increases in connectivity between salience, default mode, somatomotor, control, and dorsal attention networks that were further linked to reductions in comorbid psychological symptoms. CONCLUSIONS AND INFERENCES: Overall, Responders compared to Nonresponders showed widespread RSFC changes suggesting a shift from a predominantly inward, ruminative focus to one characterized by more externally focused attention to the body and the environment. The results suggest that MBSR may improve IBS symptom severity via impact on the brain's RSFC.

Indexed as

BrainIrritable Bowel SyndromeMindfulnessStress, PsychologicalAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedTreatment Outcomeassociation network analysesbrain functional connectivityirritable bowel syndromemindfulnessresponder analyses

Identifiers

PMID41968401
PMCPMC13071138

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.