Evidence map›Paper›PMID 41968454›Full record

ArticleCNS neuroscience & therapeutics2026

ANGPT2/Tie2 Enhances H3K18la-Mediated Macrophage M2 Polarization to Promote Endothelial Cell Proliferation in the Chronically Ischaemic Brain.

Chuyang Tai, Cong Ling, Yang Yang, Ni Mo, Cian Yao, Songtian Lv, Baoyu Zhang, Hui Wang, Chuan Chen

Abstract read
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Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Chuyang TaiDepartment of Neurosurgery, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0009-0008-5953-7079
Cong LingDepartment of Neurosurgery, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0001-8886-1857
Yang YangDepartment of Radiology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Ni MoDepartment of Neurosurgery, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Cian YaoDepartment of Neurosurgery, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Songtian LvDepartment of Neurosurgery, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Baoyu ZhangDepartment of Neurosurgery, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Hui WangDepartment of Neurosurgery, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Chuan ChenDepartment of Neurosurgery, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0009-0000-4316-4388

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2025A1515012390Basic and Applied Basic Research Foundation of Guangdong Province 2026A1515012992Basic Research Project of Sun Yat-sen University b202408011053050001Key Technologies Research and Development Program of Guangzhou Municipality 2023B03J0191
6 · The paper itself

Abstract

aimsThis study aimed to investigate the specific mechanism by which angiopoietin-2 (ANGPT2)/Tie2 signaling in macrophages promotes endothelial cell (EC) proliferation in the chronically ischaemic brain (CIB).

methodsWe first analyzed the polarization status of primary Tie2-expressing macrophages (TEMs) and Tie2-overexpressing THP-1-derived macrophages (Tie2-TDMs) following ANGPT2 treatment and detected the expression of representative proangiogenic factors. Subsequently, lysine lactylation (Kla) levels were measured, and chromatin immunoprecipitation (ChIP) assays were performed to explore the downstream activity of ANGPT2/Tie2 signaling. Additionally, in vitro functional assays using human umbilical vein endothelial cells (HUVECs) and in vivo experiments in a rat model of chronic cerebral ischaemia were conducted to confirm the effect of ANGPT2/Tie2-regulated macrophages on angiogenesis.

resultsIn response to ANGPT2 treatment, the expression of M2 polarization markers and proangiogenic factors increased in TEMs and Tie2-TDMs. Concurrently, LDHA and H3K18la were elevated, and ChIP assays confirmed the regulatory role of ANGPT2/Tie2 signaling in H3K18la-mediated transcriptional regulation. The viability of HUVECs cocultured with Tie2-TDMs was increased. Finally, ANGPT2 overexpression increased M2-polarized TEM infiltration in the CIB; additionally, rats injected with ANGPT2-pretreated TEMs exhibited more prominent EC proliferation.

conclusionANGPT2/Tie2 induces the H3K18la-mediated M2 polarization of macrophages to facilitate EC proliferation and angiogenesis in the CIB.

Indexed as

Angiopoietin-2Brain IschemiaCell ProliferationEndothelial CellsMacrophagesReceptor, TIE-2AnimalsCell PolarityCells, CulturedHumansHuman Umbilical Vein Endothelial CellsMaleRatsRats, Sprague-DawleySignal TransductionAngiopoietin-2ANGPT2 protein, humanReceptor, TIE-2angiogenesisencephalomyosynangiosisendothelial cellhistone H3 lysine 18 lactylationmacrophage polarizationTie2‐expressing monocytes/macrophages

Identifiers

PMID41968454
PMCPMC13070873

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.