Evidence map›Paper›PMID 41968708›Full record

ReviewCNS neuroscience & therapeutics2026

The Roles of Macrophage Lineage Cells (MLCs) in Brain Aging.

Qin Qin, Liubin Zhang, Manning Guo, Danli Lu, Yuxin Liu, Zihong Wang, Mengyan Hu, Shisi Wang, Xinmei Kang, Haotong Yi and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qin QinDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Liubin ZhangDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Manning GuoDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Danli LuDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Yuxin LiuDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Zihong WangDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Mengyan HuDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Shisi WangDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Xinmei KangDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Haotong YiDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Wei QiuDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.ORCID https://orcid.org/0000-0001-8102-8192
Zhengqi LuDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.ORCID https://orcid.org/0000-0002-2118-0368
Wei CaiDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.ORCID https://orcid.org/0000-0003-4059-4627

Funding

the Guangdong Basic and Applied Basic Research Foundation 2023A1515012530the Guangdong Basic and Applied Basic Research Foundation 2024B1515020021the National Natural Science Foundation of China 82271348
6 · The paper itself

Abstract

backgroundBrain aging poses a major public health challenge and is the primary risk factor for neurodegenerative diseases. Macrophage lineage cells (MLCs) have emerged as pivotal mediators of brain aging. While fundamental to central nervous system (CNS) homeostasis through their scavenging, detoxification, and neurotrophic functions, their transition to a senescent state is a primary driver of pathology. This shift is marked by a loss of clearance capacity and the adoption of a pro-inflammatory senescence-associated secretory phenotype (SASP).

objectivesHere, we summarize the distinct and cooperative roles of MLC subsets in brain aging. We examine the key molecular drivers of MLCs senescence and detail how subset-specific dysfunction contributes to the propagation of cellular aging and related neuropathology. Finally, we evaluate current and emerging therapeutic strategies that target MLCs senescence.

conclusionWe conclude by proposing a multidimensional management framework for brain aging. This framework positions MLCs as a central therapeutic hub, integrating advanced diagnostics and stratified interventions to preserve brain health and mitigate neurodegenerative pathology.

Indexed as

AgingBrainCell LineageMacrophagesAnimalsCellular SenescenceHumansNeurodegenerative Diseasesborder‐associated macrophagebrain agingmicrogliamonocyte‐derived macrophage

Identifiers

PMID41968708
PMCPMC13071362

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.