Evidence map›Paper›PMID 41968945›Full record

ReviewJournal of biomedical materials research. Part A2026

Innovations in Implant Osseointegration: Biomaterials, Surface Engineering, and Translational Strategies.

Yujin Ahn, Purva K Desai, Anna Rainey, Jose L Ayala-Ortiz, Selvarangan Ponnazhagan, Shawn R Gilbert, Ho-Wook Jun, Kyounga Cheon

Abstract readReview
In one paragraph

Review in Journal of biomedical materials research. Part A, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yujin AhnDepartment of Biomedical Engineering, School of Engineering, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Purva K DesaiDepartment of Biomedical Engineering, School of Engineering, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Anna RaineyDepartment of Biomedical Engineering, School of Engineering, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jose L Ayala-OrtizDepartment of Orthopaedic Surgery, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Selvarangan PonnazhaganDepartment of Pathology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Shawn R GilbertDepartment of Orthopaedic Surgery, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Ho-Wook JunDepartment of Biomedical Engineering, School of Engineering, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Kyounga CheonDepartment of Pediatric Dentistry, School of Dentistry, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Funding

Dual action nanomatrix coated stent evaluation using engineered artery sheets with atherosclerotic featuresR01HL163802 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JUN, HO-WOOK · 2022 to 2025
$2.6M
Biomimetic Nitric Oxide and Hydroxyapatite Duo for Advanced Direct Pulp CappingR21DE034497 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHEON, KYOUNGA · 2025 to 2025
$408k
Alabama Research and Development Enhancement Fund 1ARDEF22 09Alabama Research and Development Enhancement Fund 1ARDEF23 02NHLBI NIH HHS R01 HL163802NIDCR NIH HHS R21 DE034497NIH HHS R01HL163802NIH HHS R21DE034497
6 · The paper itself

Abstract

Osseointegration is critical for the long-term success of orthopedic and dental implants. This review highlights the biological mechanisms underlying bone-implant integration and recent advances in bioactive materials, drug delivery systems, and surface modification strategies. Implant design features-such as geometry, porosity, and coating technologies-are discussed alongside in vitro and in vivo evaluation models. Clinical applications span orthopedics, dentistry, prosthetics, and maxillofacial reconstruction. Emerging approaches, including nitric oxide-releasing coatings and controlled BMP-2 delivery, offer promising solutions to complications such as infection and ectopic ossification. These integrated strategies aim to enhance implant stability, functionality, and long-term clinical outcomes.

Indexed as

Biocompatible MaterialsDental ImplantsOsseointegrationProstheses and ImplantsTranslational Research, BiomedicalAnimalsHumansSurface PropertiesBiocompatible MaterialsDental Implantsbiomedical engineeringbone‐implant interfaceimplant surface modificationorthopedic and dental implantsosseointegration

Identifiers

PMID41968945
PMCPMC13312432

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.