Evidence mapPaperPMID 41969281Full record

ReviewNon-coding RNA research2026

Transfer RNA-derived small RNAs in cardiovascular diseases: Progress and perspectives.

Xinru Wen, Simin Wang, Hongyan Chen, Huihui Zhang, Yuqiang Ji

Abstract readReview
In one paragraph

Review in Non-coding RNA research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xinru WenThe College of Life Sciences, Northwest University, Xi'an 710127, China.
Simin WangThe First Affiliated Hospital of Northwest University, Xi'an 710002, Shaanxi, China.
Hongyan ChenThe First Affiliated Hospital of Northwest University, Xi'an 710002, Shaanxi, China.
Huihui ZhangThe College of Life Sciences, Northwest University, Xi'an 710127, China.
Yuqiang JiThe First Affiliated Hospital of Northwest University, Xi'an 710002, Shaanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

tRNA-derived small RNAs (tsRNAs) are a class of noncoding RNAs (ncRNAs) generated via the site-specific enzymatic cleavage of mature or precursor tRNAs. They are ubiquitously expressed across diverse species and are detectable in numerous cell lineages and extracellular fluids like blood and serum. They regulate gene expression at multiple levels and are functionally implicated in pivotal biological processes, including cell cycle regulation and immune response modulation. Accumulating evidence has implicated tsRNAs in both the initiation and development of cardiovascular diseases (CVDs). This article provides an overview of the classification and biological functions of tsRNAs before delving into their specific roles and mechanisms in cardiovascular pathophysiology. It aims to offer perspectives on novel therapeutic strategies, as well as the early diagnosis and prognosis assessment of CVDs.

Indexed as

biological functionsCardiovascular diseasestsRNA

Identifiers

PMID41969281
PMCPMC13068523

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.