Evidence map›Paper›PMID 41969969›Full record

ArticleJournal of molecular and cellular cardiology plus2026

T-tubular remodeling occurs in a cardiomyocyte-autonomous manner following pathological mechanical stiffness exposure.

Michael Ibrahim, Vasiliki Courelli, Lan Cheng, Leo Song, Blanca Pamias-Lopez, Alexia Vite, Omar Toubat, Fotios Pitoulis, Benjamin Prosser, Kenneth Margulies

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Michael IbrahimCardiovascular Institute, University of Pennsylvania, USA.
Vasiliki CourelliCardiovascular Institute, University of Pennsylvania, USA.
Lan ChengCardiovascular Institute, University of Pennsylvania, USA.
Leo SongCardiovascular Institute, University of Pennsylvania, USA.
Blanca Pamias-LopezCardiovascular Institute, University of Pennsylvania, USA.
Alexia ViteCardiovascular Institute, University of Pennsylvania, USA.
Omar ToubatDivision of Cardiovascular Surgery, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Fotios PitoulisCardiovascular Institute, University of Pennsylvania, USA.
Benjamin ProsserCardiovascular Institute, University of Pennsylvania, USA.
Kenneth MarguliesCardiovascular Institute, University of Pennsylvania, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T-tubules are invaginations of the cardiomyocyte sarcolemma, essential for excitation-contraction coupling and calcium-induced calcium release. Disruption of T-tubule structure contributes to contractile dysfunction in heart failure, yet the mechanisms driving this remodeling remain poorly understood. Here, we investigated whether mechanical load alone, independent of neurohormonal signals and extracellular matrix cues, is sufficient to induce pathological remodeling of T-tubules in isolated cardiomyocytes. Using a magnetorheological elastomer (MRE) culture system with tunable stiffness, we subjected adult rat cardiomyocytes to mechanical microenvironments spanning that of healthy (10 kPa) and diseased (50 kPa) myocardium. We assessed Ca

Indexed as

Extracellular stiffnessHeart failureMechanical loadRemodelingT-tubules

Identifiers

PMID41969969
PMCPMC13068527

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.