Evidence map›Paper›PMID 41970255›Full record

ArticleMaterials today. Bio2026

Glucose-responsive "sense-and-treat" microneedle patch for promoting diabetic chronic wound healing.

Yan Zhou, Lin He, Shunyuan Xie, Min Zhang, Lanlin Qi, Mingjian Chen, Lamei Liu, Yuchen Wu, Kemin Wang, Xiaoxiao He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yan ZhouState Key Laboratory of Chemo and Biosensing, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Changsha, 410082, China.
Lin HeState Key Laboratory of Chemo and Biosensing, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Changsha, 410082, China.
Shunyuan XieState Key Laboratory of Chemo and Biosensing, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Changsha, 410082, China.
Min ZhangState Key Laboratory of Chemo and Biosensing, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Changsha, 410082, China.
Lanlin QiState Key Laboratory of Chemo and Biosensing, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Changsha, 410082, China.
Mingjian ChenState Key Laboratory of Chemo and Biosensing, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Changsha, 410082, China.
Lamei LiuState Key Laboratory of Chemo and Biosensing, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Changsha, 410082, China.
Yuchen WuState Key Laboratory of Chemo and Biosensing, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Changsha, 410082, China.
Kemin WangState Key Laboratory of Chemo and Biosensing, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Changsha, 410082, China.
Xiaoxiao HeState Key Laboratory of Chemo and Biosensing, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Changsha, 410082, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic chronic wound, plagued by hyperglycemia-driven oxidative stress, bacterial infection, and impaired angiogenesis, represent a critical biomedical challenge with limited treatment options and dire clinical outcomes. Herein, a glucose-responsive "sense-and-treat" microneedle (MN) patch was designed for on-demand drug release and comprehensive diabetic chronic wound therapy. The multifunctional MN patch (denoted EAG-MNs patch) was fabricated from two functional precursors. Solution A was consisted of phenylboronic acid modified gelatin (PBA-Gel) complexed with epigallocatechin gallate (EGCG) through dynamic boronic ester bonds to provide glucose responsiveness. Solution B contained silver nanoparticle-decorated graphene oxide (AgGO) dispersed in hyaluronic acid (HA) to enable sustained antibacterial action. Upon exposure to hyperglycemic wound microenvironment, the boronic ester bonds undergo dissociation, triggering the rapid release of EGCG to scavenge reactive oxygen species, alleviate inflammation, and promote angiogenesis. Simultaneously, the dissolved AgGO component ensures robust and long-lasting antibacterial activity against prevalent pathogens. In an infected diabetic mouse wound model, the EAG-MNs patch significantly accelerated wound closure, reduced granulation tissue formation, enhanced collagen deposition and vascularization, and effectively eliminated bacterial infection compared to control groups. This intelligent MNs platform exemplifies a novel "sense-and-treat" paradigm for diabetic chronic wound management by actively sensing pathological cues and executing synergistic therapeutic actions, offering a promising versatile strategy for advanced wound care.

Indexed as

Diabetic chronic woundGlucose-responsiveMicroneedle patchMultifunctionalSense-and-treat

Identifiers

PMID41970255
PMCPMC13067117

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.