ArticleHealth science reports2026
Feasibility and Outcomes of Clazosentan in Ruptured Vertebrobasilar Dissecting Aneurysms: A Retrospective Cohort Study.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
Background and Aims: Subarachnoid hemorrhage (SAH) caused by ruptured vertebrobasilar dissecting aneurysms (VBDAs) is associated with high morbidity and mortality rates. Although clazosentan is effective in preventing cerebral vasospasm after SAH due to saccular aneurysms, its efficacy and safety have not yet been established in patients with ruptured VBDAs. We aimed to evaluate the efficacy and safety of clazosentan in patients with SAH due to ruptured VBDAs. Methods: We conducted a retrospective cohort study of patients treated for SAH due to ruptured VBDAs at a single institution between January 2017 and March 2025. The patients were divided into the clazosentan ( Results: A total of 38 patients were included in the study. The severity of SAH did not differ significantly between the two groups (World Federation of Neurosurgical Societies grades IV-V: 60.0% vs. 64.3%, Conclusion: Clazosentan use in patients with SAH due to VBDAs appeared to be feasible and generally well tolerated without apparent excess harm. Larger prospective studies with adequate sample size are warranted to clarify the effect on clinical outcomes.
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