Evidence map›Paper›PMID 41970474›Full record

ArticleCirculation reports2026

Risk Factors for Venous Thromboembolism in Advanced Non-Small Cell Lung Cancer: A Nationwide Administrative Database Study.

Tetsuya Kimura, Yugo Yamashita, Yasutaka Ihara, Megumi Mizutani, Ryota Kawai, Ayumi Shintani

Abstract read
In one paragraph

Article in Circulation reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tetsuya KimuraDepartment of Medical Statistics, Graduate School of Medicine, Osaka Metropolitan University Osaka Japan.
Yugo YamashitaDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University Kyoto Japan.
Yasutaka IharaDepartment of Medical Statistics, Graduate School of Medicine, Osaka Metropolitan University Osaka Japan.
Megumi MizutaniDepartment of Respiratory Medicine, Graduate School of Medicine, Osaka Metropolitan University Osaka Japan.
Ryota KawaiDepartment of Medical Statistics, Graduate School of Medicine, Osaka Metropolitan University Osaka Japan.
Ayumi ShintaniDepartment of Medical Statistics, Graduate School of Medicine, Osaka Metropolitan University Osaka Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Non-small cell lung cancer (NSCLC) is associated with a high risk of venous thromboembolism (VTE). However, data on specific risk factors for VTE in patients with advanced NSCLC remain limited. Methods and Results: Using a Japanese nationwide administrative database, we analyzed 20,206 patients aged ≥18 years with advanced NSCLC who received first-line chemotherapy between January 2016 and January 2023. VTE events were identified through International Classification of Diseases, Tenth Revision codes and imaging studies. Risk factors were evaluated using Cox proportional hazards models with time-dependent covariates. The cumulative incidence of VTE was 4.2% and 6.1% at 365 and 730 days after the first date of chemotherapy for NSCLC, respectively. Several significant risk factors for VTE were identified, including female sex (hazard ratio [HR] 1.374; 95% confidence interval [CI] 1.157-1.631), higher body mass index (HR 1.029 per 1-kg/m Conclusions: This large-scale study identified several significant risk factors for VTE in patients with advanced NSCLC. The findings suggest the need for risk-stratified monitoring and prophylactic strategies to reduce VTE-related complications in high-risk patients.

Indexed as

Nationwide databaseNon-small cell lung cancerRisk factorVenous thromboembolism

Identifiers

PMID41970474
PMCPMC13065461

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.