Evidence map›Paper›PMID 41970508›Full record

ArticleCurrent developments in nutrition2026

Variations of Dietary Intake Across Migraine Phases in Adults with Episodic Migraine: A Prospective Observational Pilot Study.

Maryann R Greenfield, Cara Frankenfeld, Anjali Pendala, Alexandra Ozmeral, Vyshnavi Pendala, Nora Baustian, Elizabeth K Seng, Jelena M Pavlovic, Raedeh Basiri, Margaret Slavin

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Article in Current developments in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Maryann R GreenfieldUniversity of Maryland, Department of Nutrition and Food Science, College Park, MD, United States.
Cara FrankenfeldMaineHealth Institute for Research, Center for Interdisciplinary Population & Health Research, Scarborough, ME, United States.
Anjali PendalaGeorge Mason University, Department of Nutrition and Food Studies, Fairfax, VA, United States.
Alexandra OzmeralYeshiva University, Ferkauf Graduate School of Psychology, Bronx, NY, United States.
Vyshnavi PendalaGeorge Mason University, Department of Nutrition and Food Studies, Fairfax, VA, United States.
Nora BaustianUniversity of Maryland, Department of Nutrition and Food Science, College Park, MD, United States.
Elizabeth K SengYeshiva University, Ferkauf Graduate School of Psychology, Bronx, NY, United States.
Jelena M PavlovicAlbert Einstein College of Medicine, Saul R. Korey Department of Neurology, Bronx, NY, United States.
Raedeh BasiriGeorge Mason University, Department of Nutrition and Food Studies, Fairfax, VA, United States.
Margaret SlavinUniversity of Maryland, Department of Nutrition and Food Science, College Park, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Migraine is a common and disabling neurological disorder with complex symptoms, which may include eating-related symptoms before, during, and after headache (HA) pain. Objectives: This study aimed to use a novel case-crossover design to assess dietary intake in temporal relation to migraine attacks. Methods: Data were collected from 25 people with migraine over a 28 d period, consisting of twice weekly dietary recalls combined with daily HA diaries assessing migraine symptoms. Micro- and macronutrient intakes were assessed, along with dietary quality. Generalized estimating equations assessed relationships between migraine attack phases and day-level dietary intake. Results: Participants included 23 females and 2 males, with a mean (M) age of 31 ± 12 y and with a mean migraine disability assessment score in the severe range at 28.6 ± 20.2. Vitamin D and choline had the lowest frequencies of participants meeting the Dietary Reference Intakes. During the prodrome phase, the Healthy Eating Index (HEI) component score for total protein foods [M: 4.6; 95% confidence interval (CI): 4.4, 4.9], calories from total protein (M: 19.6%; 95% CI: 17.1%, 22.0%), and animal protein (M: 13.4%; 95% CI: 10.8%, 16.1%) were significantly higher than on interictal days [(M: 4.1; 95% CI: 3.9, 4.4), (M: 15.7%; 95% CI: 14.5%, 16.9%), and (M: 9.6%; 95% CI: 8.4%, 10.8%), respectively]. On HA days with mild pain, total HEI scores [(M: 61.9; 95% CI: 53.8, 69.9), total vegetable HEI component (M: 4.4; 95% CI: 3.9, 5.0)], greens/beans component (M: 3.8; 95% CI: 2.7, 4.9) and fiber density (M: 15.6 g/1000 kcal; 95% CI: 12.8, 18.3 g/1000 kcal)], were higher than on HA days with severe pain [(M: 52.6; 95% CI: 47.5, 57.8), (M: 3.1; 95% CI: 2.5, 3.8), (M: 2.3; 95% CI: 1.4, 3.1), and (M: 11.1; 95% CI: 9.2, 13.0), respectively]. Conclusions: A study design utilizing a novel combination of dietary recalls and HA diaries enables the observation of day-level differences in protein intake and dietary quality in relation to phase of the migraine attack and HA pain severity. The methodology is successful in consistently gathering detailed data that supports future designs, which represent diverse populations with migraine.

Indexed as

dietary qualitydietary recallheadachemacronutrientsmigraine

Identifiers

PMID41970508
PMCPMC13068852

What Socratic holds

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.