Evidence map›Paper›PMID 41972001›Full record

ArticleiScience2026

Circadian disruption exacerbates MASH by reducing

Hanxin Xue, Danyi Zeng, Yanying You, Jianwei Zhang, Xiaoning Chen, Qingqing Xing, Weiwei Zeng, Minxia Wu, Jinshui Pan, Yueyong Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hanxin XueDepartment of Hepatology, Hepatology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China.
Danyi ZengDepartment of Hepatology, Hepatology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China.
Yanying YouDepartment of Hepatology, Hepatology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China.
Jianwei ZhangDepartment of Hepatobiliary Pancreatic Oncology, Fujian Cancer Hospital, Fuzhou, Fujian 350014, China.
Xiaoning ChenDepartment of Gastroenterology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China.
Qingqing XingDepartment of Hepatology, Hepatology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China.
Weiwei ZengDepartment of Hepatology, Hepatology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China.
Minxia WuDepartment of Hepatology, Hepatology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China.
Jinshui PanDepartment of Hepatology, Hepatology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China.
Yueyong ZhuDepartment of Hepatology, Hepatology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circadian disruption is a recognized risk factor for metabolic dysfunction-associated steatohepatitis (MASH). Using a mouse model combining continuous light exposure and a western diet, we found that circadian disruption exacerbated hepatic steatosis, inflammation, and intestinal barrier damage. Integrated 16S rRNA sequencing and metabolomics revealed a concurrent marked decrease in intestinal

Indexed as

metabolomicsmicrobiologymolecular biology experimental approach

Identifiers

PMID41972001
PMCPMC13062522

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.