ArticleCurrent research in food science2026
Konjac glucomannan-based nano-fiber membrane delivery system for enhancing anthocyanins stability and regulating oral mucosalpermeation.
Article in Current research in food science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study develops a core-shell hydrogel nanofiber membrane (NFM) via dynamic rheology-guided spinning and multi-component molecular design to enhance stability and bioactive delivery efficiency. The Konjac glucomannan (KGM)/Polyvinylpyrrolidone (PVP) core forms a 3D gel barrier through hydrogen bonds, inhibiting anthocyanin diffusion (PVP/KGM/ACNs@PVA 6.48 MPa mechanical strength) and enabling 97% release in 120 min. The Polyvinyl alcohol (PVA) shell stabilizes the interface via dynamic hydrogen bonds, achieving 81.22% retention after 8-day light exposure. Cytotoxicity assessment confirmed its good biocompatibility. In addition, NFM can achieve controlled release with a release rate of 97% within 120 min and has a high penetration rate in pig mucosa, with a penetration rate of 53.96% within 5 h. After penetration, it still retains significant antioxidant activity, verifying the feasibility of oral absorption. These findings highlight a rheology-driven strategy for efficient bioactive component delivery.
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