SynthesisEpigenetics2026
The role of R-loops-mediated epigenetic regulation in genome stability maintenance and disease pathogenesis: a systematic review.
Synthesis in Epigenetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This systematic review synthesizes current evidence linking R-loops - associated processes with epigenetic regulation, genome stability, and human disease, integrating findings across DNA/RNA/protein modifications and 3D genome organization, and highlighting key mechanistic and technical gaps relevant to future studies, including longer-term translational exploration. Following PRISMA guidelines (Registration No.: INPLASY202560055), PubMed and ScienceDirect databases were searched through 18 January 2026. Two independent reviewers conducted blinded screening via the Rayyan platform. From 1290 initial articles, 71 studies met inclusion criteria. Methodological rigour was assessed using a modified SYRCLE risk-of-bias tool. Thematic synthesis identifies R-loops as recurrent intermediates linking transcription, chromatin regulation, and genome maintenance; feedback-like relationships are reported in selected systems. They spatially impede DNMTs to sustain promoter hypomethylation while recruiting TET enzymes for demethylation, and RNA modifications (e.g. m5C/m6A) may tune hybrid stability and, in some contexts, influence effector recruitment. R-loops facilitate the recruitment of histone-modifying complexes (PRC1/PRC2, G9a/GLP), thereby influencing chromatin landscapes and 3D genome architecture - including associations with TAD boundary insulation and with LLPS-related repair compartments in specific contexts. Dysregulation of R-loop homeostasis links to disease-related epigenetic alterations and genome instability with distinct disease-, locus- and cell-state specificity, and its context-dependent roles in diverse disorders involve transcriptional silencing, DNA damage, replication-transcription conflicts, repair pathways, chromatin regulation and mitochondrial genome maintenance. Integrating DRIP-seq with epigenomic profiling and functional tests supports mapping of context-specific relationships.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.