ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026
ChREBP-β Exacerbates Renal Tubular Disorders Caused by Fructose via ATF4.
Ting Fang, Xinyu Yang, Xiaoqing Deng, Jingyi Wang, Ting Li, Hang Guo, Bei Sun, Liming Chen
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In one paragraphArticle in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
Ting FangNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Xinyu YangNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.ORCID https://orcid.org/0009-0000-9228-6437 Xiaoqing DengNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Jingyi WangNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Ting LiNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Hang GuoNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Bei SunNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Liming ChenNHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.ORCID https://orcid.org/0000-0002-5682-2340 Funding
MOST|National Natural Science Foundation of China (NSFC) 82305007MOST|National Natural Science Foundation of China (NSFC) 82370842Research Project of the Affiliated Hospital of Zhejiang Chinese University 2025FSYYZQ02the Natural Science Foundation of Tianjin 23JCZDJC00640Tianjin Key Medical Discipline Construction Project TJYXZDXK-3-007B
6 · The paper itselfAbstract
Excessive fructose intake is strongly associated with metabolic diseases, with the carbohydrate response element-binding protein (ChREBP) playing a key role in its metabolism, particularly in renal tubules. However, the role of its active form, ChREBP-β, was previously unclear. In this study, ChREBP-β overexpression and ChREBP knockout mouse models were utilized to investigate the effects of excessive fructose intake in vivo. In addition, primary renal tubular epithelial cells from mice and human kidney-2 (HK2) cells were applied for further validation in vitro. We found that ChREBP-β leads to increased transcription to mediate endoplasmic reticulum stress and mitochondrial dysfunction, which ultimately impairs renal function. Our findings underscore the critical role of ChREBP-β in fructose-related renal disorders.
Indexed as
Activating Transcription Factor 4Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsFructoseKidney DiseasesKidney TubulesAnimalsCell LineEndoplasmic Reticulum StressEpithelial CellsHumansMaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaActivating Transcription Factor 4Atf4 protein, mouseBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsFructoseMlxipl protein, mouseChREBP‐βendoplasmic reticulum stressfructosemitochondrial dysfunctionrenal tubular disorder
Identifiers
PMID41973151
PMCPMC13075461
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