ArticleEJNMMI physics2026
Investigation of iterative deconvolution in
Article in EJNMMI physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
AIM/
introductionQuantitative MATERIALS/
methodsThe NEMA IEC Body Phantom (foreground-to-background ratio 8:1, 237:30 kBq/mL) was measured according to the local imaging and reconstruction protocol. The two main parameters of LRD, sigma and number of iterations, were determined in two steps. First, a matched filter resolution analysis was conducted on the ground truth activity distribution as segmented from the NEMA IEC Body Phantom data to define the sigma of a 3D Gaussian point-spread-function, which describes the system's spatial resolution. Secondly, using this sigma, a suitable number of LRD iterations was determined by comparing sphere recovery coefficients (RC) and signal-to-noise ratios. The selected parameters were then applied to the reconstructed SPECT series (24, 48, and 72 h post-injection) of 20 patients who received either [
resultsA sigma of 6.0 mm and four iterations resulted in an average improvement of 18.9 ± 4.7% and 17.4 ± 7.6% in the sphere recovery coefficients and the signal to noise ratio, respectively. In total, 98 lesions were evaluated ([
conclusionOR + LRD increased AD compared to OR, independent of administered radiopharmaceutical and lesion location. This study suggests that implementing LRD may be a promising option for image-based spill-over correction in
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