Evidence map›Paper›PMID 41973352›Full record

ArticleEuropean geriatric medicine2026

The combined association of STOPPFall medication use and orthostatic blood pressure abnormalities with future falls and fractures in community-dwelling older people.

Kate Doyle, Siobhan Scarlett, Silvin P Knight, Frank Moriarty, Amanda Lavan, Robert Briggs, Rose-Anne Kenny

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Article in European geriatric medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Kate DoyleThe Irish Longitudinal Study On Ageing (TILDA), Trinity College Dublin, Dublin, Ireland. doylek7@tcd.ie.ORCID http://orcid.org/0000-0002-2083-6281
Siobhan ScarlettThe Irish Longitudinal Study On Ageing (TILDA), Trinity College Dublin, Dublin, Ireland.
Silvin P KnightThe Irish Longitudinal Study On Ageing (TILDA), Trinity College Dublin, Dublin, Ireland.
Frank MoriartyThe Irish Longitudinal Study On Ageing (TILDA), Trinity College Dublin, Dublin, Ireland.
Amanda LavanThe Irish Longitudinal Study On Ageing (TILDA), Trinity College Dublin, Dublin, Ireland.
Robert BriggsThe Irish Longitudinal Study On Ageing (TILDA), Trinity College Dublin, Dublin, Ireland.
Rose-Anne KennyThe Irish Longitudinal Study On Ageing (TILDA), Trinity College Dublin, Dublin, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSTOPPFall(Screening Tool of Older Persons Prescriptions in older adults with high fall risk) defines fall-risk-increasing drugs(FRIDs) associated with orthostatic hypotension(OH)/falls. This study assesses the association between the cumulative effect of STOPPFall medications and OH, on future falls/fractures, over 4-year follow-up among community-dwelling older people ≥ 65 years using The Irish Longitudinal Study on Ageing(TILDA) data.

methodsSTOPPFall medications were recorded at Wave1. Orthostatic blood pressure(BP) was measured by active stand using a Finometer at Wave1, recording delayed BP recovery(drop in systolicBP(sBP) ≥ 20 mmHg and/or diastolicBP ≥ 10 mmHg from baseline at 30 s post-stand) and "any OH"(same BP drop at any of 30,60,90,120 s post-stand). Falls/fractures were self-reported. Logistic regression models using interaction terms generated odds ratios(ORs) assessing the association between the interaction of STOPPFall medications and delayed BP recovery/any OH at baseline, and falls(including injurious/unexplained falls) and all fractures at follow-up.

results1390 participants were included, mean age at baseline 71.0 years, 51% female. One STOPPFall medication was prescribed in 27%(372/1390) participants, 11%(147/1390) were prescribed ≥ 2STOPPFall medications. Over 40% participants fell during follow-up(592/1390,42.6%), 12%(160/1390) sustained fractures. The cumulative effect of ≥ 2STOPPFall medications and delayed BP recovery was independently associated with all falls[OR1.93(95%CI1.04-3.59);p = 0.036], injurious falls[OR2.97(95%CI1.55-5.68);p = 0.001] and all fractures[OR3.50(95%CI1.66-7.41);p = 0.001]. Prescription of ≥ 2STOPPFall medications and any OH was independently associated with all falls[OR1.98(95%CI1.11-3.54);p = 0.021], injurious falls[OR2.25(95%CI1.21-4.20);p = 0.011] and all fractures[OR2.81(95%CI1.34-5.90);p = 0.006].

conclusionPrescription of ≥ 2 STOPPFall medications and delayed BP recovery, and prescription of ≥ 2 STOPPFall medications and any OH, was associated with all falls, injurious falls and all fractures. This highlights the importance of multidomain interventions during multifactorial falls assessments.

Indexed as

Accidental FallsFractures, BoneHypotension, OrthostaticAgedAged, 80 and overAging in PlaceBlood PressureFemaleHumansIndependent LivingIrelandLongitudinal StudiesMaleRisk FactorsBlood pressureDeprescribingFall-risk-increasing drugsInjurious fallsOlder peopleOrthostatic hypotension

Identifiers

PMID41973352
PMCPMC13309396

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.