ArticleJournal of diabetes2026
Genomic Structural Equation Modeling Reveals Cardiovascular-Kidney-Metabolic Syndrome Genetic Architecture.
Article in Journal of diabetes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
backgroundThe genetic basis of cardiovascular-kidney-metabolic syndrome (CKMs) involves complex pleiotropy, necessitating analytical approaches capable of dissecting shared genetic architectures across multiple cardiometabolic traits.
methodsWe employed genomic structural equation modeling (genomic SEM) to integrate summary statistics from six cardiometabolic traits. The model was assessed using standard fit indices. Genome-wide association analyses were performed on 1,862,425 SNPs under stringent quality control measures, with LD Score regression applied to evaluate polygenic heritability and confounding bias. Novel loci were identified using GWAS-by-Subtraction. Functional characterization included transcriptome-wide association analysis (TWAS), fine-mapping, pathway enrichment analysis, and cell-type specificity analysis.
resultsThe genomic SEM model demonstrated excellent fit (CFI = 0.99, SRMR = 0.14). Quality control metrics confirmed that genomic inflation (Lambda GC = 1.591) was primarily attributable to polygenic heritability (h
conclusionsOur study unravels the shared genetic architecture of CKMs, revealing novel risk loci and pathogenic mechanisms. The results establish a direct cellular link between the pleiotropic genetic basis of CKMs and endocrine metabolic regulation within pancreatic islets.
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