Evidence map›Paper›PMID 41974989›Full record

ArticleNatural products and bioprospecting2026

Sophflarines F-K: matrine-based alkaloids with a rare aromatic system from Sophora flavescens and their anti-inflammatory and synergistic antibacterial effects.

Ding Luo, Le-Yan Wang, Xiang-Feng Zhao, Xiao-Lin Huang, Yang-Yi Hu, Qiong-Yun Jing, Yan-Jun Chen, He Tian, Si-Yan Chen, Yu-Yan Wang and 3 more

Abstract read
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In one paragraph

Article in Natural products and bioprospecting, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ding Luo *Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.ORCID http://orcid.org/0009-0009-3428-819X
Le-Yan Wang *Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Xiang-Feng Zhao *Department of Anesthesiology, The First Affifiliated Hospital of Jinan University, Guangzhou, 510000, China.
Xiao-Lin HuangGuangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Yang-Yi HuGuangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Qiong-Yun JingGuangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Yan-Jun ChenDepartment of Anesthesiology, The First Affifiliated Hospital of Jinan University, Guangzhou, 510000, China.
He TianDepartment of Anesthesiology, The First Affifiliated Hospital of Jinan University, Guangzhou, 510000, China.
Si-Yan ChenGuangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Yu-Yan WangGuangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Xian-Hui HuangGuangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. xhhuang@scau.edu.cn.
Zhen-Ling ZengGuangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. zlzeng@scau.edu.cn.
Xiao-Ping LiaoGuangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. xpliao@scau.edu.cn.

Funding

National Natural Science Foundation of China 82273803National Natural Science Foundation of China 82304320the Administration of Traditional Chinese Medicine of Guangdong Province 20251086the Innovative Research Groups of the National Natural Science Foundation of China 32121004the National Key Research and Development Program of China 2023YFD1800101
6 · The paper itself

Abstract

Six new matrine-based alkaloids, sophflarines F-K (1-6), featuring a rare aromatic system, were obtained from the water-soluble alkaloid fractions of Sophora flavescens by UV-guided separation. Their structures were elucidated by the interpretation of spectroscopic analyses, quantum chemical calculation, and X-ray diffraction data. Compounds 1 and 2 represent highly modified 15,16-seco-17-nor-matrine derivatives incorporating a rare 4,5-dihydro-3H-pyrrolo[2,3,4-ij]quinolizine moiety, while compound 5 possesses an unusual 6/6/6-5 tetracyclic skeleton. A copper sulfate-induced zebrafish assay revealed that compounds 1, 4, and 5 exhibited moderate anti-inflammatory activity at non-toxic concentrations. Checkerboard assays demonstrated that compounds 5 and 6 potentiated colistin activity against Escherichia coli ATCC25922 and BW25113-mcr-1, reducing colistin MIC values by 16- and 32-fold, respectively. These findings expand the structural diversity of aromatic matrine-type alkaloids and highlight their potential as anti-inflammatory agents and antibacterial adjuvants.

Indexed as

Antibacterial synergyAnti inflammatoryMatrine type alkaloidsSophora flavescensX-Ray diffraction

Identifiers

PMID41974989
PMCPMC13076842

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.