Evidence mapPaperPMID 41975191Full record

ReviewNPJ systems biology and applications2026

Targeting protein protein interactions and their modulators to enable new therapeutic strategies for human diseases.

Aftab Alam, Maria J Fernandez Cabezudo, Rifat Hamoudi, Basel K Al-Ramadi

Abstract readReview
In one paragraph

Review in NPJ systems biology and applications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aftab AlamDepartment of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. aftabal@uaeu.ac.ae.
Maria J Fernandez CabezudoDepartment of Biochemistry and Molecular Biology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Rifat HamoudiResearch Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Basel K Al-RamadiDepartment of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. ramadi.b@uaeu.ac.ae.

Funding

Al Jalila Foundation grant #AJF201709 (Dubai, UAE)Hamdan Awards Grant # MRG-231 2017/2018 (Sheikh Hamdan Al-Maktoum Award for Medical Sciences, Dubai)Zayed Center for Health Sciences (#31R088), Office of Research and Sponsored Projects, United Arab Emirates University #31R088
6 · The paper itself

Abstract

Protein-protein interactions (PPIs) are essential for cellular processes and play central roles in disease mechanisms, making them important therapeutic targets. This review explores how integrating artificial intelligence (AI) and deep learning (DL) with traditional experimental approaches has advanced the mapping and analysis of PPIs. We discuss how systems biology leverages PPI networks to model diseases and identify novel therapeutic targets, and highlight challenges and future directions in multi-omics integration, AI-driven innovation, and network-based drug development.

Indexed as

Protein Interaction MappingProtein Interaction MapsSystems BiologyArtificial IntelligenceDeep LearningHumansProteinsProteins

Identifiers

PMID41975191
PMCPMC13265768

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.