Evidence map›Paper›PMID 41977342›Full record

ArticleInternational journal of molecular sciences2026

Intestinal Epithelial-like Cells Stimulated by a Functional Food Ingredient Promote Lysyl Oxidase (LOX) Expression in Osteoblast Precursor Cells via BMP-1 Secretion.

Naoki Fujimoto, Shotaro Suzuki, Tomohiro Yano, Shinji Sakata, Yuka Ito, Tatsuya Ishida

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Naoki FujimotoGraduate School of Health and Sports Sciences, Toyo University, Tokyo 115-8650, Japan.
Shotaro SuzukiGraduate School of Health and Sports Sciences, Toyo University, Tokyo 115-8650, Japan.
Tomohiro YanoGraduate School of Health and Sports Sciences, Toyo University, Tokyo 115-8650, Japan.ORCID 0000-0002-9490-3424
Shinji SakataAsahi Quality & Innovations, Ltd., Moriya-Shi 302-0106, Ibaraki, Japan.
Yuka ItoAsahi Quality & Innovations, Ltd., Moriya-Shi 302-0106, Ibaraki, Japan.
Tatsuya IshidaGraduate School of Health and Sports Sciences, Toyo University, Tokyo 115-8650, Japan.ORCID 0000-0002-3669-3932

Funding

Asahi Groups Holdings, Ltd. N/AInoue Enryo Memorial Foundation of Toyo University N/A
6 · The paper itself

Abstract

Osteoporosis is characterized by reductions in bone mineral density (BMD) and bone quality. While gut-derived signaling has been increasingly studied in relation to BMD, its contribution to molecular factors associated with bone quality remains less defined. Here, we investigated whether a heat-inactivated, freeze-dried, non-viable preparation of

Indexed as

Bone Morphogenetic Protein 1Epithelial CellsIntestinal MucosaOsteoblastsProtein-Lysine 6-OxidaseCaco-2 CellsHumansTransforming Growth Factor beta1BMP1 protein, humanBone Morphogenetic Protein 1Protein-Lysine 6-OxidaseTransforming Growth Factor beta1BMP-1bone qualitygut–bone crosstalkintestinal epithelial-like cellslysyl oxidaseosteoblast precursor cells

Identifiers

PMID41977342
PMCPMC13074062

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.