Evidence map›Paper›PMID 41977363›Full record

ReviewInternational journal of molecular sciences2026

RET Signaling Pathway in Human Cancer: Oncogenic Mechanisms, Selective Inhibitors, and Emerging Resistance Strategies.

Spencer Streit, Aala Dweik, Amen Mahtab, Sundas Ali, Abat Khan, Matthew Salzberg

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Spencer StreitHematology/Oncology Department, Memorial Healthcare System, Pembroke Pines, FL 33028, USA.ORCID 0000-0002-4651-2576
Aala DweikHematology/Oncology Department, Memorial Healthcare System, Pembroke Pines, FL 33028, USA.
Amen MahtabHematology/Oncology Department, Memorial Healthcare System, Pembroke Pines, FL 33028, USA.
Sundas AliHematology/Oncology Department, Memorial Healthcare System, Pembroke Pines, FL 33028, USA.
Abat KhanHematology/Oncology Department, Memorial Healthcare System, Pembroke Pines, FL 33028, USA.ORCID 0000-0002-8370-9060
Matthew SalzbergHematology/Oncology Department, Memorial Healthcare System, Pembroke Pines, FL 33028, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The proto-oncogene

Indexed as

Drug Resistance, NeoplasmNeoplasmsProtein Kinase InhibitorsProto-Oncogene Proteins c-retSignal TransductionAnimalsHumansMutationProto-Oncogene MasThyroid NeoplasmsTyrosine Kinase InhibitorsMAS1 protein, humanProtein Kinase InhibitorsProto-Oncogene MasProto-Oncogene Proteins c-retRET protein, humanTyrosine Kinase Inhibitorsresistance mechanismsRETtargeted therapytyrosine kinase

Identifiers

PMID41977363
PMCPMC13074088

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.