Cytokine Profiling for the Prediction of Lethality and High-Dose Exposure in a Murine Partial Body Irradiation Model.

Wanchang Cui, Lisa Hull, Asher Rothstein, Li Wang, Bin Lin, Min Zhai, Alia Weaver, Mang Xiao

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wanchang CuiArmed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0001-6408-8601

Lisa HullArmed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

Asher RothsteinArmed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

Li WangArmed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0003-4700-989X

Bin LinArmed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

Min ZhaiArmed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

Alia WeaverArmed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

Mang XiaoArmed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

Funding

AFRRI intramural grant AFR-11616AFRRI intramural grant AFR-15755NIH/NIAID/AFRRI Interagency Agreement (IAA) HT0011-22-D-0022

6 · The paper itself

Abstract

Accurate radiation biodosimetry is urgently needed for medical management after large-scale radiation exposure. Partial-body irradiation with 5% bone marrow sparing (PBI/BM5) provides a realistic radiation model. The current study specifically focused on the high-dose lethality window (12-16 Gy), where survival transitioned from 100% to 0%, representing a clinically distinct and underserved scenario requiring dedicated biodosimetry tools. We defined the survival profile of male C57BL/6 mice after PBI/BM5 and found that doses of 13.5-14.0 Gy were nonlethal within 12 days, whereas 15.0-15.5 Gy caused 100% mortality within 12 days, with a calculated LD

Indexed as

CytokinesAnimalsBiomarkersDose-Response Relationship, RadiationMaleMiceMice, Inbred C57BLRadiometryBiomarkersCytokinesdose discriminationexposure predictionpartial-body irradiationradiation biodosimetryserum cytokinessurvival prediction

Identifiers

PMID41977398

DOI10.3390/ijms27073213

PMCPMC13073184

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.