Evidence map›Paper›PMID 41977461›Full record

ArticleInternational journal of molecular sciences2026

Bronchial Thermoplasty Induced Changes in Blood Transcriptome Profile of Patients with Severe Asthma.

Sofi M Vassileva, Jelle M Blankestijn, Annika W M Goorsenberg, Shahriyar Shahbazi Khamas, Stefania Principe, Mahmoud I Abdel-Aziz, Abilash Ravi, Lizan D Bloemsma, Els J M Weersink, Dirk-Jan Slebos and 4 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sofi M VassilevaDepartment of Pulmonary Medicine, Amsterdam University Medical Centers, 1105 AZ Amsterdam, The Netherlands.ORCID 0009-0009-4135-6795
Jelle M BlankestijnDepartment of Pulmonary Medicine, Amsterdam University Medical Centers, 1105 AZ Amsterdam, The Netherlands.ORCID 0009-0006-2047-0888
Annika W M GoorsenbergDepartment of Pulmonary Medicine, Amsterdam University Medical Centers, 1105 AZ Amsterdam, The Netherlands.
Shahriyar Shahbazi KhamasDepartment of Pulmonary Medicine, Amsterdam University Medical Centers, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0003-3252-600X
Stefania PrincipeDepartment of Pulmonary Medicine, Amsterdam University Medical Centers, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0001-7277-699X
Mahmoud I Abdel-AzizDepartment of Pulmonary Medicine, Amsterdam University Medical Centers, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0001-9263-7137
Abilash RaviPulmoScience Lab, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Lizan D BloemsmaEpidemiology & Data Science, Amsterdam University Medical Centers, 1105 AZ Amsterdam, The Netherlands.
Els J M WeersinkDepartment of Pulmonary Medicine, Amsterdam University Medical Centers, 1105 AZ Amsterdam, The Netherlands.
Dirk-Jan SlebosGroningen Research Institute for Asthma and COPD, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0001-9555-3422
Pallav L ShahNational Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
Jouke T AnnemaDepartment of Pulmonary Medicine, Amsterdam University Medical Centers, 1105 AZ Amsterdam, The Netherlands.
Anke-Hilse Maitland-Van der ZeeDepartment of Pulmonary Medicine, Amsterdam University Medical Centers, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0002-0414-3442
Peter I BontaDepartment of Pulmonary Medicine, Amsterdam University Medical Centers, 1105 AZ Amsterdam, The Netherlands.

Funding

Boston Scientific 2013_328Stichting Astma Bestrijding 2022-016the Netherlands Lung Foundation 5.2.13.064JOZonMw, The Dutch Organisation for knowledge and innovation in health, healthcare and well-being 90713477
6 · The paper itself

Abstract

Bronchial thermoplasty (BT) is a non-pharmacological treatment for severe asthma. The working mechanism and response determinants of BT remain partly unknown. This study aims to investigate whether a systemic transcriptomic response to BT can be detected and contextualized against a control cohort. Whole blood was collected at baseline and six months after BT from severe asthma patients (

Indexed as

AsthmaBronchial ThermoplastyTranscriptomeAdultFemaleGene Expression ProfilingGene Expression RegulationHumansMaleMiddle AgedSeverity of Illness Indexbronchial thermoplastysevere asthmasystemic gene expressiontranscriptome

Identifiers

PMID41977461
PMCPMC13073894

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.