Evidence mapPaperPMID 41977487Full record

ArticleInternational journal of molecular sciences2026

Hepatocyte PPARα Is Essential for Triglyceride-Lowering Effect of Pemafibrate.

Zhe Zhang, Xuguang Zhang, Chufang Qian, Pan Diao, Takero Nakajima, Takefumi Kimura, Frank J Gonzalez, Naoki Tanaka

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhe ZhangDepartment of Global Medical Research Promotion, Shinshu University Graduate School of Medicine, Matsumoto 390-8621, Japan.
Xuguang ZhangDepartment of Global Medical Research Promotion, Shinshu University Graduate School of Medicine, Matsumoto 390-8621, Japan.
Chufang QianDepartment of Global Medical Research Promotion, Shinshu University Graduate School of Medicine, Matsumoto 390-8621, Japan.
Pan DiaoDepartment of Global Medical Research Promotion, Shinshu University Graduate School of Medicine, Matsumoto 390-8621, Japan.
Takero NakajimaDepartment of Global Medical Research Promotion, Shinshu University Graduate School of Medicine, Matsumoto 390-8621, Japan.ORCID 0000-0002-2678-788X
Takefumi KimuraDepartment of Gastroenterology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.ORCID 0000-0002-1481-1029
Frank J GonzalezCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Naoki TanakaDepartment of Global Medical Research Promotion, Shinshu University Graduate School of Medicine, Matsumoto 390-8621, Japan.ORCID 0000-0002-3212-3836

Funding

Japan Agency for Medical Research and Development (AMED) JP256f0137007Japan Agency for Medical Research and Development (AMED), Program for Basic and Clinical Research on Hepatitis JP23fk0210125the Shinshu Public Utility Foundation for Promotion of Medical Sciences none
6 · The paper itself

Abstract

We previously demonstrated that a clinically relevant dose of pemafibrate (PEM), a selective peroxisome proliferator-activated receptor α (PPARα) modulator (SPPARMα), reduces serum triglyceride (TG) levels in mice via hepatic PPARα activation. However, the specific contribution of hepatocyte PPARα remains unclear. To address this, male

Indexed as

BenzoxazolesButyratesHepatocytesPPAR alphaTriglyceridesAnimalsLiverMaleMiceBenzoxazolesButyratesPPAR alphaPpara protein, mouse(R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acidTriglycerideshepatocytepemafibratePPARαtriglyceridesβ-oxidation

Identifiers

PMID41977487
PMCPMC13072797

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.