Evidence map›Paper›PMID 41978122›Full record

Trial reportNutrients2026

Appetite Perception and Cerebral Blood Flow in Aging Adults Following a Single Bout of Exercise.

Steven K Malin, Daniel J Battillo, David H Zald, Joslyn Ramirez

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07675499 (Effects of Intranasal Insulin Plus Exercise Training on Brain Blood Flow, Neuronal Insulin Signaling, and Cognition in Adults With Type 2 Diabetes), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07675499 phase2 / phase3recruitingnot on this map

Effects of Intranasal Insulin Plus Exercise Training on Brain Blood Flow, Neuronal Insulin Signaling, and Cognition in Adults With Type 2 Diabetes

TypeinterventionalSponsorRutgers, The State University of New JerseyRan2026 to 2029Enrolled60ConditionsType 2 Diabetes, Insulin Sensitivity/Resistance, Cognition, Brain Blood FlowArmsIntranasal Insulin, Intranasal Placebo, High Intensity Exercise
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Steven K MalinDepartment of Kinesiology and Health, Rutgers University, New Brunswick, NJ 08901, USA.ORCID 0000-0002-7360-6711
Daniel J BattilloDepartment of Kinesiology and Health, Rutgers University, New Brunswick, NJ 08901, USA.
David H ZaldCenter for Advanced Human Brain Imaging Research, Rutgers University, Piscataway, NJ 08854, USA.
Joslyn RamirezDepartment of Kinesiology and Health, Rutgers University, New Brunswick, NJ 08901, USA.

Funding

NIH HHS R01DK133598-01A1Rutgers Brain Health Institute NA
6 · The paper itself

Abstract

Insulin acts in the brain to promote satiety. Aging individuals may have brain insulin resistance and altered appetite perceptions. However, it is unclear if exercise impacts cerebral reward centers and appetite perception in middle-aged to older individuals.

Indexed as

AgingAppetiteBrainCerebrovascular CirculationExerciseBlood GlucoseFemaleGlucose Tolerance TestHumansInsulinMagnetic Resonance ImagingMaleMiddle AgedPerceptionSedentary BehaviorThalamusBlood GlucoseInsulinbrain insulin resistancecerebrovascular diseasefeeding behaviortype 2 diabetes

Identifiers

PMID41978122
PMCPMC13074863

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.