Evidence mapPaperPMID 41978126Full record

ReviewNutrients2026

Research Advances of Neuroregulatory Effects of Dietary Polyphenols on Obesity Complications.

Tingting Han, Limeng Wei, Wei Gu, Sen Zheng, Yiqun Du, Huifang Ge, Daxiang Li, Zhongwen Xie

Abstract readReview
In one paragraph

Review in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tingting HanNational Key Laboratory of Tea Plant Germplasm Innovation and Resource Utilization, School of Tea Sciences, Anhui Agricultural University, Hefei 230036, China.
Limeng WeiDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Wei GuLaboratory Animal Center, Anhui Medical University, Hefei 230032, China.
Sen ZhengNational Key Laboratory of Tea Plant Germplasm Innovation and Resource Utilization, School of Tea Sciences, Anhui Agricultural University, Hefei 230036, China.
Yiqun DuNational Key Laboratory of Tea Plant Germplasm Innovation and Resource Utilization, School of Tea Sciences, Anhui Agricultural University, Hefei 230036, China.
Huifang GeNational Key Laboratory of Tea Plant Germplasm Innovation and Resource Utilization, School of Tea Sciences, Anhui Agricultural University, Hefei 230036, China.ORCID 0000-0002-7321-3790
Daxiang LiNational Key Laboratory of Tea Plant Germplasm Innovation and Resource Utilization, School of Tea Sciences, Anhui Agricultural University, Hefei 230036, China.ORCID 0000-0003-3421-3816
Zhongwen XieNational Key Laboratory of Tea Plant Germplasm Innovation and Resource Utilization, School of Tea Sciences, Anhui Agricultural University, Hefei 230036, China.ORCID 0000-0002-3080-4881

Funding

China Agriculture Research System of MOF and MARA CARS-19National Key Research and Development Program of China 2021YFD1601102
6 · The paper itself

Abstract

backgroundObesity is a chronic metabolic disease that has emerged as a major global public health concern. Obesity complications refer to a range of metabolic, neurological and behavioral disorders. Complex interaction mechanisms exist between obesity and the brain, including neuroendocrine regulation, center inflammatory responses, the gut-brain axis, and obesity-related cognitive impairment. Polyphenols are naturally occurring bioactive compounds widely found in plants. Recent research indicates that polyphenols may modulate the brain through multiple pathways, thereby ameliorating obesity complications. However, no data set available to summarize neuroregulatory effects of dietary polyphenols on obesity complication.

methodsThe latest data available were collected to review research progress focusing on neuroregulatory roles of polyphenols on obesity complication.

resultsThis review summarizes the interaction between obesity and the brain and further explores the effects of polyphenols on obesity-related neurological disorders, with particular emphasis on their roles in appetite regulation, central neuroinflammation, brain leptin and insulin resistance, gut-brain axis modulation, and cognitive improvement. Finally, future perspectives are discussed.

conclusionsThis paper may provide a new theoretical support and research direction for the potential of polyphenols against obesity-related neurological complications.

Indexed as

BrainDietObesityPolyphenolsAnimalsAppetite RegulationHumansInsulin ResistanceNervous System DiseasesPolyphenolsbraindietary polyphenolsgut–brain axisobesity complications

Identifiers

PMID41978126
PMCPMC13074678

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.