Evidence map›Paper›PMID 41978133›Full record

ArticleNutrients2026

Prenatal Edible Bird's Nest Supplementation Attenuates Offspring Skin Pigmentation via Dual Inhibition of CREB and ERK Signaling to Downregulate MITF-TYR Axis.

Wenrui Zhang, Yijia Zhang, Xinyuan Wang, Yujuan Chen, Liqin Chen, Jie Gao, Yixuan Li, Dongliang Wang, Yanan Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wenrui ZhangKey Laboratory of Functional Dairy, Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
Yijia ZhangKey Laboratory of Functional Dairy, Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
Xinyuan WangKey Laboratory of Functional Dairy, Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
Yujuan ChenKey Laboratory of Functional Dairy, Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
Liqin ChenBeijing Xiaoxian Dun Biotechnology Co., Ltd., Beijing 100024, China.
Jie GaoBeijing Xiaoxian Dun Biotechnology Co., Ltd., Beijing 100024, China.
Yixuan LiKey Laboratory of Functional Dairy, Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
Dongliang WangBeijing Xiaoxian Dun Biotechnology Co., Ltd., Beijing 100024, China.ORCID 0000-0001-9272-8071
Yanan SunKey Laboratory of Functional Dairy, Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.

Funding

Beijing Xiaoxian Dun Biotechnology Co., Ltd 202005523141358
6 · The paper itself

Abstract

BACKGROUND/

objectivesEdible bird's nest (EBN) benefits skin, but its transgenerational effects are unknown. This study investigated whether maternal EBN or its key component, sialic acid (SA), could program offspring skin pigmentation and antioxidant capacity.

methodsPregnant Sprague-Dawley rats were supplemented with EBN or equi-sialic acid SA. Offspring skin brightness (

resultsMaternal EBN induced a dose-dependent skin-brightening effect in offspring. High-dose EBN increased skin

conclusionsThis study demonstrates that maternal EBN intake programs offspring skin towards a lighter phenotype and enhanced antioxidant status through multi-faceted regulation of melanogenesis. The superior efficacy of whole EBN over pure SA highlights the value of the intact food matrix, suggesting EBN as a promising functional food for maternal nutrition.

Indexed as

Cyclic AMP Response Element-Binding ProteinDietary SupplementsMAP Kinase Signaling SystemMicrophthalmia-Associated Transcription FactorSkin PigmentationAnimalsAntioxidantsDown-RegulationFemaleMaternal Nutritional Physiological PhenomenaMelaninsMelanogenesisN-Acetylneuraminic AcidPregnancyRatsRats, Sprague-DawleyAntioxidantsCyclic AMP Response Element-Binding ProteinMelaninsMicrophthalmia-Associated Transcription FactorN-Acetylneuraminic Acidantioxidantedible bird’s nestmaternal nutritionpigmentation

Identifiers

PMID41978133
PMCPMC13074263

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.